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L2261

毛花苷C

≥97% (TLC)

别名:

C 级镧, 地高辛 C, 异丙酰胺, 毛花苷C

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关于此项目

经验公式（希尔记法）:
C49H76O20
化学文摘社编号:
17575-22-3
分子量:
985.12
NACRES:
NA.25
PubChem Substance ID:
24896307
UNSPSC Code:
12352201
EC Number:
241-546-1
MDL number:
MFCD00869432
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Quality Level

100

assay

≥97% (TLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

C[C@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](OC(C)=O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](C)O3)[C@@H](C)O2)O[C@H]5CC[C@@]6(C)[C@H](CC[C@@H]7[C@@H]6C[C@@H](O)[C@]8(C)[C@H](CC[C@]78O)C9=CC(=O)OC9)C5

InChI

1S/C49H76O20/c1-21-43(67-38-17-32(53)44(22(2)62-38)68-39-18-33(64-24(4)51)45(23(3)63-39)69-46-42(58)41(57)40(56)34(19-50)66-46)31(52)16-37(61-21)65-27-9-11-47(5)26(14-27)7-8-29-30(47)15-35(54)48(6)28(10-12-49(29,48)59)25-13-36(55)60-20-25/h13,21-23,26-35,37-46,50,52-54,56-59H,7-12,14-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29-,30+,31+,32+,33+,34-,35-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46+,47+,48+,49+/m1/s1

InChI key

JAYAGJDXJIDEKI-PTGWOZRBSA-N

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相关类别

Application


  • 肝细胞癌中的强心苷敏化：研究表明，通过涉及活性氧生成、p38MAPK 激活、线粒体转化和自噬调节的机制，毛花苷C增强了肝细胞癌细胞对TRAIL诱导的细胞凋亡的敏感性（Rasheduzzaman et al., 2019）。

  • 未分化人胚胎干细胞的消除：研究表明毛花苷C选择性地消除未分化人胚胎干细胞，揭示了其在确保干细胞治疗安全性中的潜在用途（Lin et al., 2017）。

Other Notes

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - STOT RE 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN2652
BCCK3455
BCCF9273
BCCF2230
BCCB8247

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Davy Guillarme et al.
Journal of chromatography. A, 1216(15), 3232-3243 (2009-03-03)
The UHPLC strategy which combines sub-2 microm porous particles and ultra-high pressure (>1000 bar) was investigated considering very high resolution criteria in both isocratic and gradient modes, with mobile phase temperatures between 30 and 90 degrees C. In isocratic mode
Min-Wu Chao et al.
Scientific reports, 7, 46134-46134 (2017-04-08)
Recent studies have revealed that cardiac glycosides, such as digitalis and digoxin, have anticancer activity and may serve as lead compounds for the development of cancer treatments. The poor prognosis of hepatocellular carcinoma (HCC) patients reflects the development of resistance
A Tracqui et al.
Journal of chromatography. B, Biomedical sciences and applications, 692(1), 101-109 (1997-04-25)
An original method based upon high-performance liquid chromatography coupled to ionspray mass spectrometry (HPLC-ISP-MS) has been developed for the identification and quantification in plasma of several cardiac glycosides, namely digoxin, digitoxin, lanatoside C and acetyldigitoxin. After single-step liquid-liquid extraction by
F Orosz et al.
Analytical biochemistry, 156(1), 171-175 (1986-07-01)
A rapid extraction method followed by high-performance liquid chromatographic assay was developed for the quantitative determination of the cardioactive glycosides of Digitalis lanata. The leaf samples were extracted with water or aqueous alcohols. The simple extraction method gives a better
A Takeshita et al.
Japanese circulation journal, 50(7), 671-674 (1986-07-01)
We examined whether digitalis augments cardiopulmonary baroreflex control of forearm vascular resistance in normal young men. Cardiopulmonary baroreceptor input was reduced with lower body negative pressure (LBNP) at 10 and 20 mmHg which decreased central venous pressure (CVP) but did
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全球贸易项目编号

货号GTIN
L2261-100MG04061838339331
L2261-1G04061826756430

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