产品名称
脂多糖 来源于大肠杆菌 026:B6, purified by gel-filtration chromatography
biological source
Escherichia coli (O26:B6)
form
lyophilized powder
purified by
gel-filtration chromatography
impurities
<5% Protein
color
white to faint yellow
solubility
water: 4.90-5.10 mg/mL, cloudy to hazy, colorless to faintly yellow
shipped in
ambient
storage temp.
2-8°C
Quality Level
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Application
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征成分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，TLR4是Toll样受体蛋白家族的成员，该家族可识别常见的病原体相关分子模式（PAMP）。
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的破坏。
General description
该产品是从大肠杆菌血清型 O26:B6中提取的，并已通过凝胶过滤进行纯化。源菌株是ATCC 12795。来自血清型 026的LPS：B6是来自大肠杆菌的唯一 LPS，其在SDS-PAGE 上表现出短链长行为。该 LPS的短链长度接近突变粗糙株 LPS的短链长。该LPS血清型已经以1 μg/ml用于刺激中性粒细胞。
Preparation Note
本品溶于水(5 mg/ml)或细胞培养基（1 mg/ml），得到浑浊的淡黄色溶液。以盐水为溶剂时，经过涡旋并加热至70-80 oC后，得到浓度更高但仍然浑浊的溶液（20 mg/ml）。脂多糖分子可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中，可观察到混浊的溶液。使用有机溶剂不会得到更澄清的溶液。以甲醇为溶剂将得到含漂浮物的混浊悬浮液，而以水为溶剂将得到均匀的混浊溶液。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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