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Key Documents

L3023

Sigma-Aldrich

脂多糖 来源于大肠杆菌 0111:B4

Detoxified

别名:

LPS

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About This Item

EC 号:
MDL编号:
UNSPSC代码:
12352201
NACRES:
NA.25

生物来源

Escherichia coli (O111:B4)

质量水平

形式

lyophilized powder

颜色

white to beige

溶解性

water: soluble

运输

ambient

储存温度

2-8°C

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一般描述

本品从 O111:B4 血清型大肠杆菌中提取,经色谱法纯化。来源菌株来自私人收藏。脂质 A 部分已通过碱水解部分脱脂。去除类脂 A 的脂肪酸部分可产生一种去毒 LPS,其内毒素级别比母体 LPS 低 10,000 倍。

应用

脂多糖(LPS)是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式(PAMP)的Toll样受体蛋白家族成员Toll样受体4(TLR4)刺激先天性免疫系统细胞。

生化/生理作用

脂多糖(LPS)位于膜的外层,并且在非包封的菌株中,其暴露于细胞表面。它们有助于外膜的完整性,并可保护细胞免受胆汁盐和亲脂性抗生素的作用。

制备说明

色谱纯化;碱水解脱脂
该产品可溶于水(5mg / ml)或细胞培养基(1mg / ml),产生浑浊的淡黄色溶液。当涡旋并升温至70-80 oC后,在盐水中可获得更高浓度的溶液(20mg/ml),但仍然是浑浊的溶液。脂多糖是一种在各种溶剂中都形成胶束的分子。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。有机溶剂无法使溶液变澄清。甲醇会产生含有漂浮物的混浊悬浮液,而水会产生均匀的混浊溶液。

其他说明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

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Fernando F Anhê et al.
Cell reports, 36(11), 109691-109691 (2021-09-16)
Lipopolysaccharides (LPSs) can promote metabolic endotoxemia, which is considered inflammatory and metabolically detrimental based on Toll-like receptor (TLR)4 agonists, such as Escherichia coli-derived LPS. LPSs from certain bacteria antagonize TLR4 yet contribute to endotoxemia measured by endotoxin units (EUs). We
Hua Qiu et al.
Drug design, development and therapy, 13, 589-600 (2019-02-28)
Jie-Du-Hua-Yu (JDHY) granule is a combination of six traditional Chinese medicines with known therapeutic effect in treating acute liver failure (ALF). The aim of this study was to investigate the amelioration efficacy of JDHY in lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced ALF in rat
Carol L Ladner-Keay et al.
Prion, 10(6), 466-483 (2016-12-03)
Conversion of native cellular prion protein (PrPc) from an α-helical structure to a toxic and infectious β-sheet structure (PrPSc) is a critical step in the development of prion disease. There are some indications that the formation of PrPSc is preceded
Gabrielle R Andrade et al.
Human vaccines & immunotherapeutics, 10(10), 2864-2874 (2014-12-09)
E. coli O111 strains are responsible for outbreaks of blood diarrhea and hemolytic uremic syndrome throughout the world. Because of their phenotypic variability, the development of a vaccine against these strains which targets an antigen that is common to all
Gabriela Cruz-Carrillo et al.
Frontiers in neuroscience, 14, 452-452 (2020-06-26)
Fetal programming by hypercaloric intake leads to food addiction-like behavior and brain pro-inflammatory gene expression in offspring. The role of methylome modulation during programming on central immune activation and addiction-like behavior has not been characterized. We employed a nutritional programming

相关内容

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

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