L3129
脂多糖 来源于大肠杆菌 0127:B8
purified by phenol extraction
别名:
LPS
生物来源
Escherichia coli (O127:B8)
质量水平
表单
lyophilized powder
纯化方式
phenol extraction
杂质
<3% Protein (Lowry)
颜色
white to faint yellow
溶解性
water: soluble
运输
ambient
储存温度
2-8°C
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一般描述
该产物是从大肠杆菌血清型O127：B8中苯酚提取得到。源菌株为ATCC 12740。该LPS血清型已经用于脓毒性休克的研究，并且可在大鼠肾小球masangial细胞中诱导小鼠巨噬细胞和PAF中的NOS合成。
应用
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。
生化/生理作用
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。
制备说明
该产品可溶于水（5mg/mL）或细胞培养基（1mg/mL），并产生浑浊的淡黄色溶液。在涡旋并升温至70-80 oC后，在盐水中可获得更加浓缩但仍然浑浊的溶液（20mg/ml）。脂多糖是一种能在各种溶剂中形成胶束的分子。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。通过有机溶剂无法获得更澄清的溶液。在甲醇会产生含有漂浮物的混浊悬浮液，而在水中则产生均匀的浑浊溶液。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Geoffroy Laumet et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 43(13), 2597-2605 (2018-07-29)
In humans, depression is often associated with low-grade inflammation, activation of the tryptophan/kynurenine pathway, and mild lymphopenia. Preclinical research confirms that inflammation induces depression-like behavior through activation of the tryptophan/kynurenine pathway. However, the mechanisms governing recovery from depression are unknown.
Irene Söderhäll et al.
The Journal of biological chemistry, 284(10), 6301-6310 (2009-01-09)
Melanization is an important immune component of the innate immune system of invertebrates and is vital for defense as well as for wound healing. In most invertebrates melanin synthesis is achieved by the prophenoloxidase-activating system, a proteolytic cascade similar to
Marumi Ohno et al.
Shock (Augusta, Ga.), 50(2), 248-254 (2018-07-17)
Co-chaperone cytoplasmic constitutive active/androstane receptor retention protein (CCRP), a member of heat shock protein (HSP) 40, was first characterized to retain a nuclear-destined protein in the cytoplasm. Here we have used CCRP KO mice and demonstrated that CCRP suppresses lipopolysaccharide
Micaela Domingues et al.
Frontiers in neuroscience, 12, 486-486 (2018-08-04)
Inasmuch, as the major depressive disorder (MDD) has been characterized as a heterogeneous disease as the inflammatory processes, neurotrophic factors' dysfunction and oxidative/nitrosative stress are believed to play a vital role in its establishment. Organoselenium compounds stand out due to
Jeffrey A Haspel et al.
Nature communications, 5, 4753-4753 (2014-09-12)
Circadian rhythms are known to regulate immune responses in healthy animals, but it is unclear whether they persist during acute illnesses where clock gene expression is disrupted by systemic inflammation. Here we use a genome-wide approach to investigate circadian gene
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