推荐产品
生物来源
Escherichia coli (O111:B4)
质量水平
无菌性
γ-irradiated
产品线
BioXtra
形式
lyophilized powder
纯化方式
gel-filtration chromatography
储存条件
desiccated
技术
cell based assay: suitable
cell culture | mammalian: suitable
杂质
<1% Protein (Lowry)
溶解性
H2O: 5 mg/mL, slightly hazy
应用
clinical research
life science and biopharma
储存温度
2-8°C
正在寻找类似产品? 访问 产品对比指南
一般描述
脂多糖 (LPS) 是由脂质和多糖组成的复杂分子，主要存在于革兰氏阴性菌的外膜中。LPS 由脂质 A、核心低聚糖 (core) 和 O 特异性多糖或 O 抗原 (Oag) 组成，固定在细菌外膜上，脂质 A 主要负责其相关毒性。作为促炎反应的有效激活剂，LPS 参与多种哺乳动物细胞，包括巨噬细胞、单核细胞和内皮细胞。在保护革兰氏阴性菌免受环境胁迫的同时，LPS 也在感染过程中触发先天免疫系统的识别。
应用
该LPS血清型已用于刺激B细胞并在人肝细胞中诱导NOS。
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。
生化/生理作用
脂多糖是绝大多数革兰氏阴性菌细胞壁的一种主要组成成分。它是一种高免疫原性抗原，具有增强针对可溶性抗原免疫应答的能力。LPS还可作为来自小鼠、兔、鸡、牛、仓鼠和人骨髓来源的B淋巴细胞的一种特异性促分裂原。
特点和优势
- 高纯度化合物适用于各种研究应用
重悬
脂多糖以经γ-射线处理的冻干粉形式提供。如需重悬，可将1 ml无菌的平衡盐溶液或组织培养基加入至小瓶（1 mg）中并轻轻晃动直至粉末溶解。重悬后的产品可采用无菌的平衡盐溶液或组织培养基进一步被稀释至所需的工作浓度。
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jennifer Vandooren et al.
Haematologica, 102(10), 1671-1682 (2017-08-05)
Lipopolysaccharides or endotoxins elicit an excessive host inflammatory response and lead to life-threatening conditions such as endotoxemia and septic shock. Lipopolysaccharides trigger mobilization and stimulation of leukocytes and exaggerated production of pro-inflammatory molecules including cytokines and proteolytic enzymes. Matrix metalloproteinase-9
Christopher R Shaler et al.
PLoS biology, 15(6), e2001930-e2001930 (2017-06-21)
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome
Chuan Yan et al.
Journal of hepatology, 63(2), 420-428 (2015-04-02)
Chronic inflammation is a major etiological factor for hepatocellular carcinoma (HCC), but how immune cells respond in the initiation of hepatocarcinogenesis remains uncharacterized. This study aims to investigate the response and roles of neutrophils in early hepatocarcinogenesis. By inducible expression
Kelly L Brown et al.
Journal of immunology (Baltimore, Md. : 1950), 186(9), 5497-5505 (2011-03-29)
The human cathelicidin peptide, LL-37, is a host defense peptide with a wide range of immunomodulatory activities and modest direct antimicrobial properties. LL-37 can exert both pro- and anti-inflammatory effects and can modulate the proinflammatory responses of human peripheral blood
Wei Shao et al.
The Journal of biological chemistry, 282(50), 36321-36329 (2007-10-26)
Caspase-1 is an essential effector of inflammation, pyroptosis, and septic shock. Few caspase-1 substrates have been identified to date, and these substrates do not account for its wide range of actions. To understand the function of caspase-1, we initiated the
商品
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门