生物来源
Salmonella enterica (Serotype enteritidis)
质量水平
表单
lyophilized powder
纯化方式
phenol extraction
杂质
<3% Protein (Lowry)
颜色
white to faint yellow
溶解性
water: 0.90-1.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow
运输
ambient
储存温度
2-8°C
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一般描述
本品为肠炎沙门菌中提取的苯酚。来源菌株为 ATCC 13076。肠炎沙门氏菌的脂多糖在小鼠脾细胞中具有致突变性，并在这些细胞中引起空斑形成反应。
应用
脂多糖 (LPS) 是革兰氏阴性菌细胞壁的特征性成分。LPS 及其脂质 A 部分通过 Toll 样受体 4 (TLR4) 刺激天然免疫系统的细胞。
生化/生理作用
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中，其暴露于细胞表面。它们有助于外膜的完整性，并可保护细胞免受胆汁盐和亲脂性抗生素的作用。
制备说明
该产品可溶于水（5mg / ml）或细胞培养基（1mg / ml），产生浑浊的淡黄色溶液。当涡旋并升温至70-80 oC后，在盐水中可获得更高浓度的溶液（20mg/ml），但仍然是浑浊的溶液。脂多糖是一种在各种溶剂中都形成胶束的分子。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。有机溶剂无法使溶液变澄清。甲醇会产生含有漂浮物的混浊悬浮液，而水会产生均匀的混浊溶液。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Roua Abulkassim et al.
Journal of neuroimmunology, 295-296, 139-147 (2016-05-29)
Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using
Ferdinando Nicoletti et al.
Autoimmune diseases, 2010, 757432-757432 (2010-12-29)
Androstenediol (androst-5-ene-3β,17β-diol; 5-AED), a natural adrenal steroid, has been shown to suppress experimental autoimmune encephalomyelitis (EAE) in female SJL/J mice. We here report that 5-AED limits inflammation and proinflammatory cytokines including TNFα in murine models of carrageenan-induced pleurisy and lippopolysaccaride-
G L Cooper et al.
Infection and immunity, 62(11), 4747-4754 (1994-11-01)
Newly hatched chicks were vaccinated orally with a genetically defined Salmonella enteritidis aroA candidate, strain CVL30. In chickens immunized with 10(5) or 10(9) CFU and challenged by the intravenous route with 10(8) CFU of S. enteritidis 109 Nalr at 8
G Wildbaum et al.
The Journal of clinical investigation, 106(5), 671-679 (2000-09-07)
This study used naked DNA vaccination to induce breakdown of tolerance to self and thus elicit immunological memory to native, membrane-bound Fas ligand (FasL). Upon induction of experimental autoimmune encephalomyelitis (EAE), this memory was turned on to provide protective immunity.
Sofia Agelaki et al.
Infection and immunity, 70(11), 6068-6074 (2002-10-16)
Corticotropin-releasing hormone (CRH) exerts an anti-inflammatory effect indirectly, via cortisole production, and a proinflammatory effect directly on immune cells. The aim of the present work was to examine the effect of CRH on macrophage-derived cytokines both in vitro and in
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