生物来源
Salmonella enterica (serotype typhimurium)
质量水平
无菌性
γ-irradiated
产品线
BioXtra
表单
lyophilized powder
纯化方式
gel-filtration chromatography
技术
cell culture | mammalian: suitable
杂质
<1% Protein (Lowry)
储存温度
2-8°C
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应用
已经使用来自肠沙门氏菌血清型鼠伤寒沙门氏菌的脂多糖：
- 在小鼠中，诱发促炎细胞因子的分泌
- 在单核细胞中，诱导细胞因子的产生
- 在小鼠树突状细胞中，诱导 NF-κB通路的激活。
- 在人结肠腺癌 Caco-2细胞中，诱导炎症反应
- 用于刺激鲶鱼外周血白细胞（PBL），以研究雌激素受体 mRNA的表达
脂多糖（LPS）是革兰氏阴性细菌细胞壁的特征组分。LPS及其脂质A部分通过Toll样受体4（TLR4）刺激先天免疫系统的细胞，Toll样受体 4是Toll样受体蛋白家族的成员，其识别常见的病原体相关分子模式（PAMP）。
生化/生理作用
LPS是大多数革兰氏阴性细菌的细胞壁的主要成分。它是一种高免疫原性抗原，具有增强对可溶性抗原的免疫应答的能力。LPS 还作为来自小鼠、兔、鸡、牛、仓鼠和人的骨髓来源的B 淋巴细胞的特异性促分裂原。
制备说明
脂多糖以冻干的γ-辐射粉末形式提供。要重悬，将 1ml 无菌平衡盐溶液或组织培养基加入小瓶（1mg）中，并轻轻旋转直至粉末溶解。可使用无菌平衡盐溶液或组织培养基将重悬产物进一步稀释至所需的工作浓度。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Luke R Iwanowicz et al.
Fish & shellfish immunology, 40(1), 109-119 (2014-06-29)
Estrogens are recognized as modulators of immune responses in mammals and teleosts. While it is known that the effects of estrogens are mediated via leukocyte-specific estrogen receptors (ERs) in humans and mice, leucocyte-specific estrogen receptor expression and the effects of
Guangwei Xu et al.
Journal of enzyme inhibition and medicinal chemistry, 33(1), 1089-1094 (2018-06-23)
Indoleamine 2,3-dioxygenase 1 (IDO1) activity links to immune escape of cancers. Inhibition of IDO1 provides a new approach for cancer treatment. Most clinical IDO1 drugs show marginal efficacy as single agents. On basis of molecular docking and pharmacophore modelling, a
Anna R Tröscher et al.
Acta neuropathologica, 137(4), 619-635 (2019-01-22)
Microglia nodule formation is a common feature in inflammatory brain diseases mediated by T lymphocytes such as viral and paraneoplastic encephalitis, multiple sclerosis, and Rasmussen encephalitis (RE). However, its role has not been fully understood yet. We hypothesized that, in
Stefania De Santis et al.
Oncotarget, 7(46), 75800-75809 (2016-10-08)
Dendritic cells (DCs) are professional antigen presenting cells (APCs) that in response to microbial infections generate long-lasting adaptive immune response. Following microbial uptake, DCs undergo a cascade of cellular differentiation that ultimately leads to "mature" DCs. Mature DCs produce a
Mike Tsz Hin Ng et al.
Infection and immunity, 78(3), 1345-1352 (2009-12-30)
Colonization of the gastric mucosa by Helicobacter pylori can lead to serious clinical outcomes, including gastric cancer. Toll-like receptors (TLRs) play an important role in the host response to H. pylori through the recognition of pathogen-associated molecular patterns. TLR9, in
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