L9133
亮氨酸脑啡肽 乙酸盐 水合物
≥95% (HPLC), μ- and δ-opioid receptor agonist
别名:
亮氨酸脑啡肽
Product Name
亮氨酸脑啡肽 乙酸盐 水合物, ≥95% (HPLC)
质量水平
方案
≥95% (HPLC)
储存温度
−20°C
SMILES字符串
O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
InChI
1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1
InChI key
QKDIOZBQOQJXFR-XQCXOTTHSA-N
基因信息
human ... OPRD1(4985), OPRM1(4988)
mouse ... OPRD1(18386), OPRM1(18390)
rat ... OPRD1(24613), OPRM1(25601)
Amino Acid Sequence
Tyr-Gly-Gly-Phe-Leu
一般描述
亮氨酸脑啡肽是一种五肽，是中央和周围组织的正常成分。亮氨酸脑啡肽的氨基酸序列为 Tyr-Gly-Gly-Phe-Leu，分布在包括人在内的多种动物的大脑中。它是一种内源性阿片类神经递质/神经调节剂，位于大脑中和δ受体类似的位置。
应用
亮氨酸脑啡肽乙酸盐盐水合物已用于单级 TOF 模式下 Q-Tof Micro 混合，三重四极杆正交飞行时间（TOF）质谱仪的校准。它也已用于进行质谱的校准。它也已被用于液相色谱-质谱（LCMS）/ MS 中进行系统校准和光谱的相对校正。
生化/生理作用
亮氨酸脑啡肽（LEU-ENK）在 μ-和 δ-阿片受体位点均起激动剂的作用。它也可能在吗啡敏感的突触中充当神经递质。亮氨酸脑啡肽还与疼痛调节有关。骆驼泪神经中表达的 LEU-ENK 调节泪液和蛋白质分泌。LEU-ENK 在代谢过程中会被多种酶降解，包括氨基肽酶 N（APN）、中性内肽酶（NEP）、二肽基肽酶 3（DPP3）、羧基肽酶 A6（CPA-6）和血管紧张素转换酶（ACE），有时也称为脑啡肽酶。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Zhuo Cheng et al.
Frontiers in plant science, 11, 965-965 (2020-07-17)
Plants in Acorus have been used as herbal medicine by various linguistic groups for thousands of years. Arguments of taxonomy of Acorus among scientists resulted in confusions and misuses of Acorus plants. The present study used different methods to investigate
Biological effects of Trichoderma harzianum peptaibols on mammalian cells
Peltola J, et al.
Applied and Environmental Microbiology, 70(8), 4996-5004 (2004)
S R George et al.
The Journal of biological chemistry, 275(34), 26128-26135 (2000-06-08)
The existence of dimers and oligomers for many G protein-coupled receptors has been described by us and others. Since many G protein-coupled receptor subtypes are highly homologous to each other, we examined whether closely related receptors may interact with each
Pattern of distribution of neuropeptides in the camel lacrimal gland.
Adeghate E
Neuropeptides, 30(6), 566-571 (1996)
An enzyme-linked immunosorbent assay for detecting 3-phenoxybenzoic acid in plasma and its application in farmers and consumers.
Thiphom S
Analytical Methods : Advancing Methods and Applications, 4(11), 3772-3778 (2012)
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