L9133
亮氨酸脑啡肽 乙酸盐 水合物
≥95% (HPLC), μ- and δ-opioid receptor agonist
别名:
亮氨酸脑啡肽
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关于此项目
经验公式（希尔记法）:
C28H37N5O7 · xC2H4O2 · yH2O
分子量:
555.62 (anhydrous free base basis)
UNSPSC Code:
12352209
eCl@ss:
32160409
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
亮氨酸脑啡肽 乙酸盐 水合物, ≥95% (HPLC)
SMILES string
O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
InChI
1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1
InChI key
QKDIOZBQOQJXFR-XQCXOTTHSA-N
assay
≥95% (HPLC)
storage temp.
−20°C
Quality Level
Gene Information
human ... OPRD1(4985), OPRM1(4988)
mouse ... OPRD1(18386), OPRM1(18390)
rat ... OPRD1(24613), OPRM1(25601)
General description
亮氨酸脑啡肽是一种五肽，是中央和周围组织的正常成分。亮氨酸脑啡肽的氨基酸序列为 Tyr-Gly-Gly-Phe-Leu，分布在包括人在内的多种动物的大脑中。它是一种内源性阿片类神经递质/神经调节剂，位于大脑中和δ受体类似的位置。
Application
亮氨酸脑啡肽乙酸盐盐水合物已用于单级 TOF 模式下 Q-Tof Micro 混合，三重四极杆正交飞行时间（TOF）质谱仪的校准。它也已用于进行质谱的校准。它也已被用于液相色谱-质谱（LCMS）/ MS 中进行系统校准和光谱的相对校正。
Biochem/physiol Actions
亮氨酸脑啡肽（LEU-ENK）在 μ-和 δ-阿片受体位点均起激动剂的作用。它也可能在吗啡敏感的突触中充当神经递质。亮氨酸脑啡肽还与疼痛调节有关。骆驼泪神经中表达的 LEU-ENK 调节泪液和蛋白质分泌。LEU-ENK 在代谢过程中会被多种酶降解，包括氨基肽酶 N（APN）、中性内肽酶（NEP）、二肽基肽酶 3（DPP3）、羧基肽酶 A6（CPA-6）和血管紧张素转换酶（ACE），有时也称为脑啡肽酶。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
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