L9664
氯雷他定
≥98% (HPLC), Histamine H1 receptor antagonist, powder
别名:
4-（8-氯-5,6-二氢-11H-苯并[5,6]环庚[1,2-b]吡啶-11-亚基-1-哌啶羧酸乙酯, 氯雷他定
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关于此项目
经验公式（希尔记法）:
C22H23N2O2Cl
化学文摘社编号:
分子量:
382.88
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
氯雷他定, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: soluble 50 mg/mL
H2O: insoluble
创始人
Schering Plough
储存温度
2-8°C
SMILES字符串
CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
InChI
1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChI key
JCCNYMKQOSZNPW-UHFFFAOYSA-N
基因信息
human ... CYP3A4(1576), HRH1(3269), KCNH1(3756), KCNH2(3757), PTAFR(5724)
rat ... Hrh1(24448)
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相关类别
生化/生理作用
氯雷他定是一种非镇静性组胺H1受体拮抗剂。其可抑制双孔结构域钾通道K2P18.1（也称为TRESK或KCNK18）。
非镇静组胺H1-受体拮抗剂。
特点和优势
该化合物由Schering Plough开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
F M Baroody et al.
Allergy, 55 Suppl 64, 17-27 (2001-04-09)
The primary mechanism of antihistamine action in the treatment of allergic diseases is believed to be competitive antagonism of histamine binding to cellular receptors (specifically, the H1-receptors), which are present on nerve endings, smooth muscles, and glandular cells. This notion
Nemanja Kolašinac et al.
International journal of pharmaceutics, 436(1-2), 161-170 (2012-07-10)
The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of the poorly water soluble drug substance desloratadine that can be used for the preparation of immediate release tablet formulation. Two commercially available poloxamer
J Kornhuber et al.
Neuropharmacology, 34(7), 713-721 (1995-07-01)
Amantadine (1-amino-adamantane) is clinically used for the management of Parkinson's disease and drug-induced extrapyramidal symptoms. It has previously been shown that amantadine is a low-affinity uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist with rapid blocking and unblocking channel kinetics (Ki-value at the
H Ebrahimzadeh et al.
Analytica chimica acta, 767, 155-162 (2013-03-05)
In this work a molecularly imprinted polymer was developed as a selective sorbent for extraction of loratadine (as a model) in complex matrices followed by miniaturized homogeneous liquid-liquid extraction (MHLLE) for the first time. The molecularly imprinted polymer (MIP) which
M Magerl et al.
The British journal of dermatology, 166(5), 1095-1099 (2012-01-17)
Cold urticaria is a rare but severe and potentially lethal condition. It is primarily treated symptomatically with H(1) -antihistamines. However, patients have a variable response to these drugs and, to date, it has not been possible to predict readily the
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