CN
PTAFR
platelet-activating factor receptor
别名:
PAFR
物种:
Human PTAFR (5724), Mouse Ptafr (19204), Rat Ptafr (58949), domestic guinea pig Ptafr (100720710), sheep PTAFR (443041), sheep PTAFR (101104560), Goat PTAFR (100860976), cow PTAFR (518283), domestic cat PTAFR (101085906), naked mole-rat Ptafr (101711912) ...展开
UniProtKB ID:
基因ID:
- Human(5724) Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
- Mouse(19204) platelet-activating factor receptor
- Rat(58949) platelet-activating factor receptor
- domestic guinea pig(100720710) platelet-activating factor receptor
- sheep(443041) platelet-activating factor receptor
- sheep(101104560) platelet-activating factor receptor
- Goat(100860976) platelet-activating factor receptor
- cow(518283) platelet-activating factor receptor
- domestic cat(101085906) platelet-activating factor receptor
- naked mole-rat(101711912) platelet-activating factor receptor
- chicken(428209) platelet-activating factor receptor
- dog(487336) platelet-activating factor receptor
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Small Molecule - Antagonist
货号
说明
物种
Antibodies
货号
说明
物种反应性
应用
Anti-PTAFR antibody produced in mouse, purified immunoglobulin,
物种反应性
human, mouse
应用
western blot
Anti-PTAFR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry