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Merck
CN

L9793

Sigma-Aldrich

LP44

≥98% (HPLC), solid

别名:

4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphth alenyl)-1-piperazinehexanamide hydrochloride

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关于此项目

经验公式（希尔记法）:
C27H38ClN3OS
CAS Number:
824958-12-5
分子量:
488.13
MDL编号:
MFCD09971090
UNSPSC代码:
12352200
PubChem化学物质编号:
329817675
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

solid

溶解性

DMSO: >10 mg/mL
H2O: ≥2 mg/mL

储存温度

2-8°C

SMILES字符串

Cl.CSc1ccccc1N2CCN(CCCCCC(=O)NC3CCCc4ccccc34)CC2

InChI

1S/C27H37N3OS.ClH/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24;/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31);1H

InChI key

DWGKCWWWKHCVDH-UHFFFAOYSA-N

相关类别

应用

LP44 has been used as a 5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) agonist to study its effects on mitochondria-mediated leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation.

生化/生理作用

LP44 is a high affinity 5-HT7 receptor agonist.
LP44 is a high affinity 5-HT7 receptor agonist. Ki = 0.22 nM. LP44 displays selectivity over 5-HT1A and 5-HT2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
057M4610V
075M4621V
028K46101V
028K4610

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Jianshu Ni et al.
BJU international, 123(4), 718-725 (2018-05-22)
To examine the effect of intrathecal (i.t.) serotonin (5-hydroxytryptamine) 5-HT7 agonist administration on voiding function in the urethane-anesthetised rat, and the change in 5-HT7 receptor (5-HT7 R) expression in the lumbosacral cord Onuf's nucleus after spinal cord injury (SCI). In
Lynn Meurs et al.
PloS one, 6(9), e24393-e24393 (2011-09-21)
Schistosoma infection is thought to lead to down-regulation of the host's immune response. This has been shown for adaptive immune responses, but the effect on innate immunity, that initiates and shapes the adaptive response, has not been extensively studied. In
Gulsen Ayaz et al.
Biochemical genetics, 55(1), 34-47 (2016-09-03)
This study aimed to investigate the effects of the 5-HT7 receptor agonist (LP44) and antagonist (SB269970) on LPS-induced in vivo tissue damage and cell culture by molecular methods. This study was conducted in two steps. For in vivo studies, 24 female
Miriam A Snider et al.
Journal of animal science, 96(4), 1570-1578 (2018-02-23)
Prior work using a contractility bioassay determined that the serotonin (5-HT) receptor subtype 5-HT2A is present in bovine lateral saphenous veins and plays a role in ergot alkaloid (EA)-induced vascular contraction in steers grazing endophyte-infected (Epichloë coenophiala) tall fescue (Lolium
Liping Wu et al.
Journal of gastroenterology, 51(11), 1040-1049 (2016-10-28)
Serotonin regulates gastrointestinal function, and mast cells are a potential nonneuronal source of serotonin in the esophagus. Tight junction (TJ) proteins in the esophageal epithelium contribute to the barrier function, and the serotonin signaling pathway may contribute to epithelial leakage
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