M0939
抗-α-MSH 兔抗
IgG fraction of antiserum, buffered aqueous solution
别名:
抗-α-黑素细胞刺激素
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
microarray
microarray
Species reactivity:
human
Citations:
11
Technique(s):
ELISA: 1:4,000
microarray: suitable
microarray: suitable
Uniprot accession no.:
产品名称
抗-α-MSH 兔抗, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 1664.9 kDa
species reactivity
human
technique(s)
ELISA: 1:4,000
microarray: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... POMC(5443)
Application
兔体内产生的抗α-MSH抗体已用于：
- 免疫组织化学，
- 放射免疫测定/α-MSH免疫测定，
- 酶联免疫吸附测定（ELISA）
Biochem/physiol Actions
α-MSH（黑素细胞刺激激素）和黑皮质素-4受体（MC4R）是控制能量稳态和下丘脑对肥胖反应的关键信号成分。减少-MSH功能活性的突变导致哺乳动物肥胖，缺乏MC4受体（MC4R-/-）的小鼠会暴食和非常肥胖表明MC4-R转导的-MSH信号传导限制了食物摄入和体内脂肪质量。
α-黑素细胞刺激素（α-MSH）刺激黑素细胞生成黑色素并诱导色素沉着和皮肤变黑。它增加了诱导黑色素生成的酪氨酸酶的活性。α-MSH具有强效的抗炎作用，也是一种神经调节剂。α-MSH的类似物可用于研究黑色素生成和神经调节。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
阿片黑皮质素（POMC）是一种复合前肽，在下丘脑，垂体，皮肤和免疫系统中表达。该基因位于人染色体2p23.3。
Immunogen
与牛血清白蛋白结合的合成α-MSH肽。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
G Hunt et al.
Journal of cell science, 107 ( Pt 1), 205-211 (1994-01-01)
Although melanocyte stimulating hormone (MSH) peptides are known to stimulate pigmentation in man, previous reports suggest that human melanocytes are relatively unresponsive to these peptides in vitro. This may be related to the conditions under which the melanocytes were cultured.
John W Frew et al.
F1000Research, 7, 1923-1923 (2019-07-12)
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease with significant morbidity and impact on quality of life. Our understanding of the pathophysiology is incomplete, impairing efforts to develop novel therapeutic targets. Immunohistochemistry studies have produced conflicting results and no
V U Emelianov et al.
The British journal of dermatology, 166(5), 1023-1034 (2011-12-06)
The cause of follicular occlusion, a key early event in the pathogenesis of hidradenitis suppurativa (HS), also known as acne inversa, remains unknown. To identify changes, if any, in the antimicrobial peptide (AMP) and cytokine expression profile of HS affected
N Rajora et al.
Journal of leukocyte biology, 59(2), 248-253 (1996-02-01)
alpha-Melanocyte-stimulating hormone (alpha-MSH), a tridecapeptide derived from pro-opiomelanocortin, has potent antiinflammatory activity in laboratory animals. alpha-MSH inhibits nitric oxide production by murine macrophages, an influence believed to reflect activation of an autocrine circuit in these cells, one that is based
Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells
Stout GJ and Blasco MA
Disease models & mechanisms, 2(3-4), 139-156 (2009)
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