M1022
二氢辣椒碱
from Capsicum sp., ≥85% (HPLC), powder, VR1 vanilloid receptor agonist
别名:
6,7-二氢辣椒碱, N - [（4-羟基-3-甲氧基苯基）甲基]-8-亚甲基壬烯酰胺, N-(4-羟基-3-甲氧基苄基)-8-甲基壬酰胺
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关于此项目
经验公式（希尔记法）:
C18H29NO3
化学文摘社编号:
分子量:
307.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
2815150
产品名称
二氢辣椒碱, from Capsicum sp., ≥85%
InChI
1S/C18H29NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h10-12,14,20H,4-9,13H2,1-3H3,(H,19,21)
SMILES string
COc1cc(CNC(=O)CCCCCCC(C)C)ccc1O
InChI key
XJQPQKLURWNAAH-UHFFFAOYSA-N
biological source
Capsicum sp.
assay
≥85%
storage temp.
2-8°C
Quality Level
Gene Information
human ... TRPV1(7442)
rat ... Trpv4(66026)
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Application
二氢辣椒素已用于：
- 作为标准品分析内源性An2和辣椒素合成酶沉默水果中的二氢辣椒素水平
- 作为外部标准品测定不同品种辣椒中的辣椒素类物质的含量变化
- 辣椒素敏感初级传入(CSPA)神经纤维的活化或消融
Biochem/physiol Actions
VR1 辣椒素受体激动剂。
二氢辣椒素/8-甲基-N-香草基壬酰胺；N-[−4-羟基-3-甲氧苄基] 8-甲基壬酰胺(DHC)是辣椒中的辣椒素类活性组分。二氢辣椒素可降低体温，因此可作为药物诱导性低温(PIH)候选药物治疗心脏骤停(CA)患者。它可能还具有抗癌、抗炎、抗氧化、抗肥胖作用。二氢辣椒素可能有助于降低缺血再灌注(I/R)损伤中的氧化应激和抗炎作用。二氢辣椒素可抑制活化B细胞核因子κ-轻链增强子(NF-κB)信号转导通路。
Other Notes
辣椒素类似物。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
Y J Surh et al.
Life sciences, 56(16), PL305-PL311 (1995-03-10)
A new metabolic oxidation pathway of capsaicin (N-[(4-hydroxy-3-methoxyphenyl)-methyl]-8-methyl-(E)-6 -nonenamide), a major pungent and pharmacologically active principle of hot peppers, was investigated. Incubation of capsaicin with phenobarbital-induced rat liver postmitochondrial supernatant enriched with NADPH-generating system produced N-(4,5-dihydroxy-3-methoxybenzyl)-(E)-6 -nonenylamide and a more
Dihydrocapsaicin Attenuates Blood Brain Barrier and Cerebral Damage in Focal Cerebral Ischemia/Reperfusion via Oxidative Stress and Inflammatory
Janyou A, et al.
Scientific Reports, 7 (2017)
Dihydrocapsaicin-induced Hypothermia after Asphyxial Cardiac Arrest in Rats
He J, et al.
Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2016, 1858-1858 (2016)
Harnessing anthocyanin-rich fruit: a visible reporter for tracing virus-induced gene silencing in pepper fruit
Kim J, et al.
Plant methods, 13(1), 1-10 (2017)
Variability in capsaicinoid content in different landraces of Capsicum cultivated in north-eastern India
Islam Md A, et al.
Sci. Hortic., 183, 66-71 (2015)
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