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经验公式(希尔记法):
C4H6N2O2
化学文摘社编号:
分子量:
114.10
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
220-430-4
MDL number:
Beilstein/REAXYS Number:
1618960
产品名称
蝇蕈醇, powder
InChI key
ZJQHPWUVQPJPQT-UHFFFAOYSA-N
InChI
1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
SMILES string
NCC1=CC(=O)NO1
form
powder
color
white to off-white
storage temp.
2-8°C
Quality Level
Gene Information
rat ... Gabra2(29706)
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Application
蝇蕈醇已用于:
- 降低外侧杏仁核(LA)中条件性恐惧表达
- 消除雪貂的皮层细胞反应
- 灭活斑胸草雀中的巢皮层外侧巨细胞核(LMAN)
Biochem/physiol Actions
GABAA受体激动剂。
Features and Benefits
该化合物是神经科学研究推荐产品。点击此处 ,查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm。
General description
蝇蕈醇(Muscimol)是一种异噁唑类精神性物质,主要存在于毒蝇伞(Amanita muscaria)等菇类中。可降低大脑糖代谢,提高脑中的5-羟色胺浓度。蝇蕈醇具有致幻作用。与感知曲解、恶心和呕吐有关联。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
The role of the lateral amygdala in the retrieval and maintenance of fear-memories formed by repeated probabilistic reinforcement
Erlich JC, et al.
Frontiers in Behavioral Neuroscience, 6, 16-16 (2012)
Relation of cortical cell orientation selectivity to alignment of receptive fields of the geniculocortical afferents that arborize within a single orientation column in ferret visual cortex
Chapman B, et al.
The Journal of Neuroscience, 11(5), 1347-1358 (1991)
Muscimol as an ionotropic GABA receptor agonist
Johnston GAR
Neurochemical Research, 39(10), 1942-1947 (2014)
Prototypic GABA A receptor agonist muscimol acts preferentially through forebrain high-affinity binding sites
Chandra D, et al.
Neuropsychopharmacology, 35(4), 999-999 (2010)
Handbook of Mushroom Poisoning: Diagnosis and Treatment (1994)
商品
DISCOVER Bioactive Small Molecules for Neuroscience
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