产品名称
抗-MAGI-2 兔抗, IgG fraction of antiserum, buffered aqueous solution
technique(s)
microarray: suitable
western blot: 1:250 using rat brain extracts
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Magi2(113970)
Application
兔抗MAGI-2抗体适用免疫印迹和免疫标记。
Biochem/physiol Actions
膜相关的鸟苷酸激酶倒置 2（MAGI-2） 以及 MAGI-3 显示通过其 PDZ 结构域之一与肿瘤抑制因子 PTEN 相互作用，显然充当可以组装多亚基信号复合物的支架蛋白。已知通过它们的蛋白质-蛋白质相互作用结构域参与多蛋白质复合物的组装。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
General description
MAGI-2 由三个结构域组成，包括 6 个 PDZ、一个鸟苷酸激酶（GK） 和 2 个 WW 结构域。
Immunogen
与 KLH 缀合的 MAGI-2/S-SCAM 的氨基酸 554-571 对应的合成肽。
Physical form
溶于0.01 M磷酸盐缓冲液（pH 7.4）中，含有15 mM叠氮化钠。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors
Danielson E, et al.
The Journal of Neuroscience, 32(20), 6967-6980 (2012)
Synaptic localization and function of Sidekick recognition molecules require MAGI scaffolding proteins
Yamagata M and Sanes JR
The Journal of Neuroscience, 30(10), 3579-3588 (2010)
SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses
Fukaya M, et al.
Journal of Neurochemistry, 116(6), 1122-1137 (2011)
Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain
Deng F, et al.
The Journal of Neuroscience, 26(30), 7875-7884 (2006)
Bingbing Zhu et al.
Kidney international, 96(3), 642-655 (2019-06-07)
The essential role of membrane associated guanylate kinase 2 (MAGI2) in podocytes is indicated by the phenotypes of severe glomerulosclerosis of both MAGI2 knockout mice and in patients with congenital nephrotic syndrome (CNS) caused by mutations in MAGI2. Here, we
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