Merck
CN
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文件

安全信息

M2816

Sigma-Aldrich

Metastin (45-54) amide, human

≥95%

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别名:
Gene product (112-121) amide, human, KiSS-1, Kisspeptin-10
经验公式（希尔记法）:
C63H83N17O14
分子量:
1302.44
MDL编号:
MFCD03452696
PubChem化学物质编号:
329817951
NACRES:
NA.32

质量水平

200

检测方案

≥95%

UniProt登记号

Q15726

储存温度

−20°C

SMILES字符串

CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc4ccc(O)cc4)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc5ccccc5)C(N)=O

InChI

1S/C63H83N17O14/c1-34(2)24-45(58(90)74-43(18-11-23-70-63(68)69)57(89)75-44(54(67)86)26-35-12-5-3-6-13-35)73-53(85)32-72-56(88)46(27-36-14-7-4-8-15-36)77-62(94)50(33-81)80-61(93)49(30-52(66)84)79-59(91)47(28-38-31-71-42-17-10-9-16-40(38)42)78-60(92)48(29-51(65)83)76-55(87)41(64)25-37-19-21-39(82)22-20-37/h3-10,12-17,19-22,31,34,41,43-50,71,81-82H,11,18,23-30,32-33,64H2,1-2H3,(H2,65,83)(H2,66,84)(H2,67,86)(H,72,88)(H,73,85)(H,74,90)(H,75,89)(H,76,87)(H,77,94)(H,78,92)(H,79,91)(H,80,93)(H4,68,69,70)/t41-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1

InChI key

RITKWYDZSSQNJI-INXYWQKQSA-N

基因信息

human ... KISS1(3814)

Amino Acid Sequence

Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

一般描述

Metastin is also known as kisspeptin 1 (KISS1). It is encoded by KISS1 gene, that is mapped to human chromosome 1q32. Metastin is a tumor suppressor protein, made up of 145 amino acids. The protein fragments contain RFamide motif at the C- terminal end. The encoded protein is expressed in the human hypothalamus, gonads, placenta, liver and pancreas. This novel peptide is mainly isolated from the human placenta.

应用

Metastin (45-54) amide has been used in progesterone release experiments from MA-10 cells. It has also been used to induce gonadal differentiation in clownfish.

生化/生理作用

Metastin functions as a tumor suppressor via inhibiting secondary tumor growth. Activation of KISS1R (KISS1 receptor), upon binding KISS1, enhances intracellular calcium and activates MAPKs, which restricts cell motility and proliferation. Metastin acts as a potential therapeutic target for various cancers including melanoma, thyroid cancer and bladder cancer, squamous cell carcinoma of the esophagus gastric cancer, hepatocellular carcinoma and breast cancer. Metastin has a crucial role in reproduction. It regulates hypothalamic-pituitary-gonadal axis role via controlling gonadotropin-releasing hormone (GnRH) secretion and determines the onset of puberty. Mutation of the gene leads to central precocious puberty (CPP) in male and dysfunction of metastin signaling causes isolated hypogonadotropic hypogonadism (IHH) in humans and mice. Metastin has the ability to enhance the plasma levels of gonadotropins (follicle-stimulating hormone and luteinizing hormone) and stimulate ovulation in prepubertal female rats.
Metastin is an endogenous ligand to G-protein-coupled orphan receptors such as OT7T175 (also known as AXOR12) and GPR54. Novel placenta-derived hormone. The amide form of metastin is found to be 3-10 times more active than the free acid form of metastin.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat
Matsui H, et al.
Biochemical and Biophysical Research Communications, 320(2), 383-388 (2004)
Wui-Jung Shin et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 124(4), 291-298 (2016-01-27)
Downregulated expression of KiSS-1 has been correlated with tumor progression, metastasis, and patient prognosis in various human malignancies. However, there is no information regarding the expression of KiSS-1 in oral squamous cell carcinoma (OSCC). Our aims were to examine KiSS-1
Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1)
West A, et al.
Genomics, 54(1), 145-148 (1998)
Kisspeptin signalling and its roles in humans
Tng, Eng Loon
Singapore Medical Journal, 56(12), 649-649 (2015)
Ting Chen et al.
Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 4681-4688 (2020-12-11)
The well-known tumor suppressor transcriptional factor p53 has been proposed to be one of the central hubs of a functionally related and hierarchically arranged gene network coordinating pubertal timing. Our previous studies revealed that p53 is involved in the metabolic
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