M3655
D-Mannose 6-phosphate sodium salt
≥98% (HPLC)
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关于此项目
线性分子式:
C6H12O9PNa
化学文摘社编号:
分子量:
282.12
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
MDL number:
产品名称
D-Mannose 6-phosphate sodium salt, ≥98% (HPLC)
InChI
1S/C6H13O9P.Na.H/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;/h1,3-6,8-11H,2H2,(H2,12,13,14);;
SMILES string
[Na].OC(COP(O)(O)=O)C(O)C(O)C(O)C=O
InChI key
RUFPTDNHMAGVMV-UHFFFAOYSA-N
biological source
synthetic (inorganic)
assay
≥98% (HPLC)
form
powder
technique(s)
HPLC: suitable
impurities
<12% water (Karl Fischer)
color
white
solubility
water: 50 mg/mL, clear to cloudy, colorless
cation traces
Na: 7.3-9.0% (anhydrous)
storage temp.
2-8°C
Quality Level
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Application
Mannose has been used in a study to assess in vivo targeting of alveolar macrophages. It has also been used in a study to investigate genetic engineering of the phosphocarrier protein NPr.
Biochem/physiol Actions
Mannose-6-Pis a molecule bound by lectin in the immune system. It is converted to fructose 6-phosphate by mannose phosphate isomerase and is a key targeting signal for acid hydrolase precursor proteins that are transported to lysosomes.
General description
Mannose is a monosaccharide.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Yossef Lopez-de Los Santos et al.
The Journal of biological chemistry, 287(35), 29931-29939 (2012-07-07)
The Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system (PTS) in prokaryotes mediates the uptake and phosphorylation of its numerous substrates through a phosphoryl transfer chain where a phosphoryl transfer protein, HPr, transfers its phosphoryl group to any of several sugar-specific Enzyme IIA
Ningning Yang et al.
Journal of controlled release : official journal of the Controlled Release Society, 155(2), 326-330 (2011-07-19)
Triplex-forming oligonucleotides (TFOs) represent an antigene approach for gene regulation through direct interaction with genomic DNA. While this strategy holds great promise owing to the fact that only two alleles need silencing to impact gene regulation, delivering TFOs to target
Maria Francisca Coutinho et al.
Molecular genetics and metabolism, 105(4), 542-550 (2012-01-24)
Lysosomal hydrolases are synthesized in the rough endoplasmic reticulum and specifically transported through the Golgi apparatus to the trans-Golgi network, from which transport vesicles bud to deliver them to the endosomal/lysosomal compartment. The explanation of how are the lysosomal enzymes
Wei Cheong Ngeow et al.
Journal of anatomy, 219(5), 638-645 (2011-08-05)
Microsurgical repair of transected peripheral nerves is compromised by the formation of scar tissue and the development of a neuroma, thereby limiting the success of regeneration. The aim of this study was to quantify histomorphometrically the structural changes in neural
Petra Tiels et al.
Nature biotechnology, 30(12), 1225-1231 (2012-11-20)
Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells. Such enzyme therapeutics contain relatively low levels of mannose-6-phosphate, which is required to target them to the lysosomes of patient cells. Here we describe a method for
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