产品名称
抗 MAP2 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~280 kDa
antigen ~72 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MAP2(4133)
mouse ... Mtap2(17756)
rat ... Map2(25595)
Application
兔抗 MAP2 抗体可用于免疫细胞化学。
抗 MAP2 抗体适用于免疫组织化学（1:500，使用 Zamboni 固定剂固定、冷冻的小鼠脊髓和丘脑切片）、流式细胞术 (1:200-1:500)、免疫印迹（约 72 kDa 和 280 kDa）和蛋白质印迹 (1:500-1:1,000)。
Biochem/physiol Actions
微管相关蛋白2（MAP2）在星形胶质细胞和少突胶质细胞中树突状突起的形成过程中起关键作用。它可以维持微管的稳态。该蛋白在神经可塑性中起重要作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
MAP2 是一种与微管相关的蛋白，调节细胞骨架的结构和功能。该蛋白也调节神经元的形态发生和细胞增殖。MAP2和F-actin的相互作用与神经突初生（neurite initiation）和微管再组装有关。MAP2 的水平下降与传染性海绵状脑病相关。抗MAP2抗体对于人、小鼠和大鼠MAP2有特异性。
微管相关蛋白 2 (Microtubule associated protein 2，MAP2) 是一种神经元特异性蛋白，在中枢神经系统中广泛表达。它是细胞骨架蛋白中的一员。 该基因位于人类染色体 2q34 上。
Immunogen
相应的人 MAP2 残基 2-15 的合成肽。
Physical form
溶剂为含有0.02％叠氮化钠的磷酸盐缓冲盐水。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: a novel biological function of MAP2 in non-neuronal cells
Liu SY, et al.
Biochemical and Biophysical Research Communications, 366(2), 520-525 (2008)
Bogdan A Stoica et al.
Journal of neurotrauma, 31(8), 758-772 (2014-01-31)
Traumatic brain injury (TBI) causes neuronal cell death as well as microglial activation and related neurotoxicity that contribute to subsequent neurological dysfunction. Poly (ADP-ribose) polymerase (PARP-1) induces neuronal cell death through activation of caspase-independent mechanisms, including release of apoptosis inducing
Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells
Zhou Y, et al.
Neuro-Oncology, 17(12), 1578-1588 (2015)
Cory C Toth et al.
Molecular pain, 6, 16-16 (2010-03-20)
Despite the frequency of diabetes mellitus and its relationship to diabetic peripheral neuropathy (DPN) and neuropathic pain (NeP), our understanding of underlying mechanisms leading to chronic pain in diabetes remains poor. Recent evidence has demonstated a prominent role of microglial
Specific binding of dehydroepiandrosterone to the N terminus of the microtubule-associated protein MAP2
Laurine E, et al.
The Journal of Biological Chemistry, 278(32), 29979-29986 (2003)
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