M3821
Anti-Myelin Basic Protein Antibody
rabbit polyclonal
别名:
抗-MBP
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
rat, human, mouse
Citations:
55
Technique(s):
flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
Uniprot accession no.:
产品名称
抗-髓鞘碱性蛋白（MBP） 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 17-22 kDa (isoform)
antigen ~22 kDa (isoform)
antigen ~33 kDa (isoform)
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MBP(4155)
mouse ... Mbp(17196)
rat ... Mbp(24547)
Application
兔生产的抗髓磷脂碱性蛋白（MBP）抗体可用于：
- 间接免疫标记
- 免疫组化。
- 蛋白质印迹。
抗髓磷脂碱性蛋白（MBP）抗体（1：200 稀释）可用作双荧光标记中的一抗。它还可用于免疫印迹法检测髓磷脂碱性蛋白。
Biochem/physiol Actions
髓磷脂碱性蛋白（MBP）在髓鞘的形成中起重要作用，并且与各种神经障碍有关。髓磷脂碱性蛋白作为自身免疫疾病实验性变应性脑脊髓炎（EAE）中的抗原靶点。髓磷脂碱性蛋白在细胞骨架更新和膜延伸中起重要作用。此外，它还参与 Fyn 介导的信号途径、磷酸肌醇的隔离和钙稳态的调节。髓磷脂碱性蛋白作为丝裂原活化蛋白激酶（MAP）激酶的体外底物起作用，并有助于酶的纯化和功能研究。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
髓磷脂碱性蛋白（MBP）是一种亲水性蛋白质，主要在少突胶质细胞（ oligodendrocyte）中表达。它在神经系统的髓鞘形成、髓鞘形成前的信号通路和神经损伤后的髓鞘再生中起关键作用。抗髓磷脂碱性蛋白（MBP）抗体可用于蛋白质印迹和流式细胞术。兔抗髓磷脂碱性蛋白抗体与小鼠、大鼠和人髓磷脂碱性蛋白发生特异反应。
髓鞘碱性蛋白(MBP)是18.5kDa的蛋白，由定位于人类染色体18q22qter的基因编码。MBP是髓鞘的主要成分，在中枢神经系统(CNS)中高表达。
Immunogen
对应于人髓鞘碱性蛋白的残基 102-116 的合成肽。
Physical form
溶于含有 0.02％ 叠氮化钠的磷酸盐缓冲液中。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections.
Ding Y, et al.
PLoS ONE, 9 (2014)
C M Deber et al.
Clinical biochemistry, 24(2), 113-134 (1991-04-01)
Multiple sclerosis (MS) and a number of related distinctive diseases are characterized by the active degradation of central nervous system (CNS) myelin, an axonal sheath comprised essentially of proteins and lipids. These demyelinating diseases appear to arise from complex interactions
H Inouye et al.
Journal of neuroscience research, 28(1), 1-17 (1991-01-01)
To explain how the myelin proteins are involved in the organization and function of the myelin sheath requires knowing their molecular structures. Except for P2 basic protein of PNS myelin, however, their structures are not yet known. As an aid
Neurotropin? Accelerates the Differentiation of Schwann Cells and Remyelination in a Rat Lysophosphatidylcholine-Induced Demyelination Model
Matsuoka H, et al.
International Journal of Molecular Sciences, 19 (2018)
MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.
Vassall KA, et al.
The Biochemical Journal, 472, 17-32 (2015)
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