Name: Mometasone furoate
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₂₇H₃₀Cl₂O₆

CAS Number:

83919-23-7

分子量:

521.43

MDL编号:

MFCD00866003

UNSPSC代码:

51111800

PubChem化学物质编号:

329817988

NACRES:

NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D +50 to +60°, c = 0.5 in methanol

颜色

white to off-white

溶解性

DMSO: ≥20 mg/mL

创始人

Schering Plough

储存温度

2-8°C

SMILES字符串

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl

InChI

1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1

InChI key

WOFMFGQZHJDGCX-ZULDAHANSA-N

基因信息

human ... NR3C1(2908)

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应用

Mometasone furoate has been used to study its effect on Leishmania major amastigotes.

生化/生理作用

Mometasone furoate is a 17-heterocyclic intranasal corticosteroid. It is effectively used as a first-line daily intranasal therapeutic for allergic rhinitis and nasal polyposis. Mometasone furoate is also used as an adjunct to anti-bacterials for treating acute rhinosinusitis. In addition, it relieves the symptoms of asthma in both adults and adolescents by exhibiting a broad spectrum of anti-inflammatory properties.

Mometasone furoate is an anti-inflammatory glucocorticoid.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.