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文件

M6626

Sigma-Aldrich

S-甲基- L -半胱氨酸

substrate for methionine sulfoxide reductase A

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别名:
(R)-2-Amino-3-(methylmercapto)propionic acid, SMLC
线性分子式:
CH3SCH2CH(NH2)CO2H
CAS号:
1187-84-4
分子量:
135.18
Beilstein:
1721675
EC 号:
214-701-6
MDL编号:
MFCD00002612
eCl@ss:
32160406
PubChem化学物质编号:
24897098
NACRES:
NA.26

质量水平

200

形式

powder

技术

ligand binding assay: suitable

应用

peptide synthesis

储存温度

−20°C

SMILES字符串

CSC[C@H](N)C(O)=O

InChI

1S/C4H9NO2S/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1

InChI key

IDIDJDIHTAOVLG-VKHMYHEASA-N

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相关类别

生化/生理作用

S-Methyl-L-cysteine (SMLC) is a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA). SMLC is naturally present in garlic, cabbage, and turnips and has been studied as a theurapeutic for neurodegenerative diseases including Parkinson′s.
When used as a dietary supplement in the Drosphilia model of PD, SMLC increases the efficacy of the MRSA catalytic antioxidant system by providing additional substrate available leading to increased resistance to oxidative stress.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms.
Wassef, R. et al.
The Journal of Neuroscience, 21, 12808-12816 (2007)
Thambi Dorai et al.
Biomolecules, 10(1) (2019-12-22)
Abstract: Many tumors readily convert l-glutamine to α-ketoglutarate. This conversion is almost invariably described as involving deamidation of l-glutamine to l-glutamate followed by a transaminase (or dehydrogenase) reaction. However, mammalian tissues possess another pathway for conversion of l-glutamine to α-ketoglutarate
Ohki Higuchi et al.
Journal of agricultural and food chemistry, 51(24), 7208-7214 (2003-11-13)
Sulfur-containing compounds contributing to health promotion in Allium species are produced via enzymic and thermochemical reactions. Sulfur-containing amino acids and volatile organosulfur compounds were prepared for an antioxidative assay. The inhibitory activity of S-alk(en)yl-l-cysteines and their sulfoxides, volatile alk(en)yl disulfides
Ramez Wassef et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(47), 12808-12816 (2007-11-23)
Parkinson's disease (PD), a common neurodegenerative disease, is caused by loss of dopaminergic neurons in the substantia nigra. Although the underlying cause of the neuronal loss is unknown, oxidative stress is thought to play a major role in the pathogenesis
Cheng-chin Hsu et al.
The Journal of nutrition, 134(1), 149-152 (2004-01-06)
Balb/cA mice were used to study the in vivo effect of N-acetyl cysteine, S-allyl cysteine, S-ethyl cysteine, S-methyl cysteine and S-propyl cysteine, all derived from garlic, on glutathione (GSH) concentration and catalase and glutathione peroxidase (GPX) activities in plasma, kidney
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