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Merck
CN

M8693

Melanotan II 乙酸盐

≥95% (HPLC), MC3-R/MC4-R melanocortin agonist, lyophilized solid

别名:

Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2

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关于此项目

经验公式（希尔记法）:
C50H69N15O9 · xC2H4O2
化学文摘社编号:
121062-08-6
分子量:
1024.18 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD06795842

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产品名称

Melanotan II 乙酸盐, ≥95% (HPLC)

SMILES string

[nH]1cncc1C[C@@H]2NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC2=O)Cc5ccccc5)CCCN=C(N)N)Cc3c4c([nH]c3)cccc4)C(=O)N)NC(=O)[C@@H](NC(=O)C)CCCC

InChI

1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1

InChI key

JDKLPDJLXHXHNV-MFVUMRCOSA-N

assay

≥95% (HPLC)

form

lyophilized solid

color

white

solubility

H2O: soluble 5 mg/mL

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... MC3R(4159), MC4R(4160)
mouse ... MC3R(17201), MC4R(17202)
rat ... MC3R(29310), MC4R(25635)

相关类别

General description

Melanotan II诱导黑色素生成，从而增加皮肤色素沉着。是α-黑素细胞刺激素的类似物。

Application

Melanotan II乙酸盐已被用于研究其对大鼠进食和能量消耗的抑制作用。

Biochem/physiol Actions

Melanotan II 是一种 MC3-R/MC4-R 黑皮质素激动剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000527806
0000527806
0000517267
0000517267
0000232818

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Zeng-You Ye et al.
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Sympathetic nerve activity is increased in obesity-related hypertension. However, the central mechanisms involved in the increased sympathetic outflow remain unclear. The hypothalamic melanocortin system is important for regulating energy balance and sympathetic outflow. To understand the mechanisms by which the
John-Paul Baird et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 301(4), R1044-R1056 (2011-07-08)
Injections of the melanocortin 3/4 receptor (MCR) agonist melanotan II (MTII) to a variety of brain structures produces anorexia, suggesting distributed brain MCR control of food intake. We performed a detailed analysis of feeding behavior (licking microstructure analysis) after a
Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets
Jose K
Frontiers in Behavioral Neuroscience (2015)
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