M9808
抗 毒蕈碱乙酰胆碱受体 (M 1 ) 兔抗
affinity isolated antibody, lyophilized powder
别名:
乙酰胆碱受体抗体
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoblotting
immunohistochemistry
immunohistochemistry
Species reactivity:
mouse, rat
Citations:
23
Technique(s):
immunoblotting: 1:200 using rat brain membranes
immunohistochemistry: suitable
immunohistochemistry: suitable
Uniprot accession no.:
产品名称
抗 毒蕈碱乙酰胆碱受体 (M 1 ) 兔抗, affinity isolated antibody, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse, rat
technique(s)
immunoblotting: 1:200 using rat brain membranes
immunohistochemistry: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CHRM1(1128)
rat ... Chrm1(25229)
Biochem/physiol Actions
毒蕈碱乙酰胆碱受体1（M1）可调节正常的前列腺生长和降低水平的腺体分泌。毒蕈碱受体可在肿瘤进展中起主要作用。毒蕈碱乙酰胆碱受体（mAChR）可调节腺苷酸环化酶和钾通道活性。它还可刺激各种丝裂原活化蛋白激酶。M1可能有助于发现阿尔茨海默′病的治疗方法。
研究表明，大鼠中毒蕈碱胆碱能受体1（M1）的激活会导致肝脏内毒素耐受性出现变化。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
毒蕈碱乙酰胆碱受体1（M1）属于A类G蛋白偶联受体（GPCR）家族的一员，由CHRM1基因所编码。毒蕈碱受体具有位于副交感神经突触下膜上的七个跨膜结构域。CHRM1基因位于人染色体11q12.3上。
毒蕈碱胆碱能受体1（M1）在大鼠的前脑中可见。
Immunogen
人 M 1 毒蕈碱乙酰胆碱受体 (mAChR) 的 i3 胞内环的一部分的 GST 融合蛋白，对应于 227-353 氨基酸残基。1、 2
Physical form
从含有1%牛血清白蛋白和0.05%叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Anna Rebeka Oliveira Ferreira et al.
Frontiers in physiology, 13, 840179-840179 (2022-05-17)
Perturbations to nutrition during critical periods are associated with changes in embryonic, fetal or postnatal developmental patterns that may render the offspring more likely to develop cardiovascular disease in later life. The aim of this study was to evaluate whether
The relationship between plasma levels of clozapine and n-desmethyclozapine as well as m1 receptor polymorphism with cognitive functioning and associated cortical activity in schizophrenia
Kir Y, et al.
Psychiatry research. Neuroimaging, 111128-111128 (2020)
Aurelia Lugea et al.
Alcoholism, clinical and experimental research, 34(10), 1768-1781 (2010-07-16)
The mechanisms initiating pancreatitis in patients with chronic alcohol abuse are poorly understood. Although alcohol feeding has been previously suggested to alter cholinergic pathways, the effects of these cholinergic alterations in promoting pancreatitis have not been characterized. For this study
Veronica C Galvin et al.
Neuron, 106(4), 649-661 (2020-03-21)
Working memory relies on the dorsolateral prefrontal cortex (dlPFC), where microcircuits of pyramidal neurons enable persistent firing in the absence of sensory input, maintaining information through recurrent excitation. This activity relies on acetylcholine, although the molecular mechanisms for this dependence
Sophie R Thomson et al.
Neuron, 95(3), 550-563 (2017-08-05)
Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu
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