N0267
(±)-尼古丁
≥99% (TLC), nicotinic acetylcholine receptor agonist, liquid
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关于此项目
经验公式（希尔记法）:
C10H14N2
化学文摘社编号:
分子量:
162.23
UNSPSC Code:
12352210
eCl@ss:
39151701
PubChem Substance ID:
NACRES:
NA.77
Beilstein/REAXYS Number:
82108
MDL number:
产品名称
(±)-尼古丁, ≥99% (TLC), liquid
Quality Level
assay
≥99% (TLC)
form
liquid
optical activity
[α]25/D 0°(lit.)
color
yellow
solubility
ethanol: 50 mg/mL
density
1.02 g/mL at 25 °C (lit.)
SMILES string
CN1CCCC1c2cccnc2
InChI
1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
InChI key
SNICXCGAKADSCV-UHFFFAOYSA-N
Gene Information
human ... CHRNA2(1135), CHRNA3(1136), CHRNA4(1137)
rat ... Chrna3(25101), Chrna4(25590), Chrna7(25302)
Application
(±)-Nicotine has been used:
- as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
- as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
- as a test compound to study its effects on fibril formation
Biochem/physiol Actions
(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.
Prototype nicotinic acetylcholine receptor agonist.
Packaging
The material is liquid, transparent, and viscous, packaged in amber vail, and the volume inserted into each bottle is very small, It may form a thin FILM on the sides. While it may be difficult to see the material inside by the eyes, the container is not empty.
signalword
Danger
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
213.8 °F - closed cup
flash_point_c
101 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
涉药品监管产品
此项目有
Neal L Benowitz
Nicotine Safety and Toxicity, 3-7 (1998)
Alterations in the production and concentration of selected alkaloids as a function of rising atmospheric carbon dioxide and air temperature: implications for ethno-pharmacology
Ziska LH, et al.
Global Change Biology, 11(10), 1798-1807 (2005)
The effect of nicotine on the mechanical properties of mesenchymal stem cells
Ruiz JP, et al.
Cell health and cytoskeleton, 4, 29-29 (2012)
Guangxin Luan et al.
Experimental and therapeutic medicine, 23(1), 11-11 (2021-11-25)
Pulmonary emphysema is one of the most important pathological manifestations of chronic obstructive pulmonary disease and is commonly associated with cigarette smoking. Previous studies have indicated that necroptosis, a novel non-apoptotic cell death mechanism associated with inflammation and oxidative stress
W Sihver et al.
Neuroscience, 94(3), 685-696 (1999-12-01)
The laminar binding distribution of three nicotinic receptor agonists, [3H](-)nicotine, [3H]cytisine, and [3H]epibatidine, and their relation to the [3H]vesamicol binding, which is known to represent the vesicular acetylcholine transport sites, was performed employing in vitro autoradiography on the medial temporal
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N0267-500MG | 04061834092834 |
| N0267-100MG | 04061834092810 |
| N0267-1G | 04061834092827 |
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