N1019
(-)-尼古丁 半硫酸盐
≥95% (TLC), ~35 % (w/v) in H2O (based on free base)
别名:
(-)-1-甲基-2-(3-吡啶基)吡咯烷
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关于此项目
线性分子式:
(C10H14N2)2 · H2SO4
化学文摘社编号:
分子量:
422.54
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
MDL number:
InChI
1S/2C10H14N2.H2O4S/c2*1-12-7-3-5-10(12)9-4-2-6-11-8-9;1-5(2,3)4/h2*2,4,6,8,10H,3,5,7H2,1H3;(H2,1,2,3,4)/t2*10-;/m00./s1
SMILES string
OS(O)(=O)=O.CN1CCC[C@H]1c2cccnc2.CN3CCC[C@H]3c4cccnc4
InChI key
IECQULMJVNSKDB-RCWTXCDDSA-N
assay
≥95% (TLC)
form
liquid
concentration
~35 % (w/v) in H2O (based on free base)
color
dark brown
Quality Level
Gene Information
human ... CHRNA4(1137), CHRNB2(1141)
General description
Nicotine is found in the leaves of Nicotiana species. It binds to nicotinic acetylcholine receptors and inhibits endogenous neurotransmitters. Nicotine is associated with lung cancer development and reduces the efficiency of chemotherapeutic agents. It is used to treat Alzheimer′s and Parkinson′s disease.
Application
(−)-Nicotine hemisulfate salt has been used to study the influence of nicotine on the severity of choroidal neovascularization (CNV). It also has been used as a natural nectar alkaloid to study the effect of self-medication in bumblebees.
Biochem/physiol Actions
原型烟酸乙酰胆碱受体激动剂;天然异构体。
Analysis Note
Mixture of nicotine base and nicotine sulfate.
Disclaimer
Shelf-life of the solution as supplied is at least six years when stored at room temperature.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
法规信息
监管及禁止进口产品
此项目有
Nicotine increases size and severity of experimental choroidal neovascularization
Suner IJ, et al.
Investigative Ophthalmology & Visual Science, 45(1), 311-317 (2004)
Explorations of Plant?s Chemodiversity: Role of Nitrogen-Containing Secondary Metabolites in Plant Defense
Molecular Aspects of Plant-Pathogen Interaction, 309-332 (2018)
Caiqi Zhao et al.
Cell discovery, 3, 17009-17009 (2017-05-23)
Vagal circuits-α7 nAChR (α7 nicotinic acetylcholine receptor, coded by
Behavioural evidence for self-medication in bumblebees
Baracchi D, et al.
F1000Research, 4(1) (2015)
Nicotine inactivation of the proapoptotic function of Bax through phosphorylation
Xin M and Deng X
The Journal of Biological Chemistry, 280(11), 10781-10789 (2005)
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