N3876
(−)-尼古丁
≥99% (GC), Prototype nicotinic acetylcholine receptor agonist, liquid
别名:
(−)-1-甲基-2-(3-吡啶基)四氢吡咯, (S)-3-（1-甲基-2-吡咯烷基）吡啶
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产品名称
(−)-尼古丁, ≥99% (GC), liquid
InChI key
SNICXCGAKADSCV-JTQLQIEISA-N
InChI
1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
SMILES string
CN1CCC[C@H]1c2cccnc2
assay
≥99% (GC)
form
liquid
optical activity
[α]20/D −169°(lit.)
color
yellow
refractive index
n20/D 1.5265 (lit.)
solubility
ethanol: 50 mg/mL
density
1.010 g/mL at 20 °C (lit.)
Quality Level
Gene Information
human ... CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), CYP2A6(1548), KCNH1(3756)
mouse ... Chrna7(11441), Chrnb1(11443)
rat ... Chrna1(79557), Chrna2(170945), Chrna4(25590), Chrna7(25302), Chrnb2(54239), Chrnb4(25103)
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Application
- 在细胞外DNA荧光实验和中性粒细胞免疫染色中刺激中性粒细胞
- 通过细胞外DNA荧光检测和中性粒细胞免疫染色来研究新生儿慢性尼古丁暴露对尼古丁乙酰胆碱受体(nAChR)结合、细胞死亡和海马和小脑形态的影响
- 在体外研究中评估尼古丁或可替宁的根暴露对成纤维细胞形态和密度的影响
Biochem/physiol Actions
General description
Preparation Note
signalword
Danger
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
213.8 °F - closed cup
flash_point_c
101 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
What is the concentration of Product N3876, (-)-Nicotine?
This product is not a solution. It is a liquid. The physical state of (-)-Nicotine is a liquid at room temperature. It has not been dissolved in any solvent at a specific concentration to prepare a solution. The density of (-)-Nicotine as a liquid at 20 °C is 1.010 g/mL.
What is the molarity of Product N3876, (-)-Nicotine?
The molarity of (-)-Nicotine is 6.23 M based on a 100% pure compound with a density at 20 °C equal to 1.010 g/mL. If you multiply this density by 1000, you obtain g/L. If you divide g/L by the molecular weight of (-)-Nicotine which is 162.2 g/mole, you get moles per L which is molarity. [1.010 x 1000]/162.2 = 6.23 M.
Where should Product N3876, (-)-Nicotine, be stored and what sensitivities does it have?
For long-term storage, this product can be stored at room temperature. This compound is very hygroscopic and can darken in color on exposure to air and light.
What is the difference between Nicotine, Products N3876 and N0267?
Prod. No. N3876 is the naturally occurring (-) isomer while Prod. No. N0267 is a mixture of the (+) and (-) isomers.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
How can Product N3876, (-)-Nicotine, be solublized?
Product N3876, (-)-Nicotine, is soluble in ethanol. It is only miscible in water. We would recommend to solublized the product in ethanol to make a 1000x stock solution. This can then be diluted 1:1000 into aqueous buffer for use.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
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