产品名称
单克隆抗-神经丝蛋白 200 小鼠抗, clone NE14, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
NE14, monoclonal
mol wt
antigen apparent mol wt 200 kDa
contains
15 mM sodium azide as preservative
species reactivity
pig, mouse, chicken, bovine, guinea pig, rabbit, rat, human
enhanced validation
independent ( Antibodies)
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:40
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NEFH(4744)
Biochem/physiol Actions
最近确定神经丝重链（NEFH）基因是引起常染色体显性遗传轴突腓骨肌萎缩症 （CMT2cc）的原因。此基因在散发性肌萎缩侧索硬化症（ALS）的发病机制中起作用。目前认为，神经丝多肽磷酸化可通过影响神经丝与细胞质细胞器之间的相互作用，调节其功能。
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除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。
General description
单克隆抗神经丝 200（小鼠 IgM 同种型）来源于杂交瘤，该杂交瘤由小鼠骨髓瘤细胞与免疫小鼠脾细胞融合产生。神经丝是中间丝（IF）五种主要类型中的一种，主要存在于神经元起源的细胞或组织中。神经丝由三种主要蛋白组成，表观分子量分别为68 kD、160 kD和200 kD，相应命名为 NEFL（轻），NEFM（中）和 NEFH（重）。神经丝蛋白在神经元核周体中合成，组装形成丝，然后在轴突内缓慢地向突触末端移动。
Immunogen
猪脊髓。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
动植物来源生物产品
此项目有
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Jacobs JS and Miller MW
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