生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~110 kDa (cleaved)
antigen ~177 kDa
antigen ~270 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NES(10763)
mouse ... Nes(18008)
rat ... Nes(25491)
一般描述
巢蛋白(Nestin)是位于细胞质的VI型中间纤维蛋白。它在中间纤维中表达，分子量为177kDa。编码基因位于人类染色体1q23.1，具有4个外显子。
免疫原
对应于巢蛋白的残基254-270的合成肽。该序列有93％与大鼠相同。
生化/生理作用
巢蛋白（NES）是蛋白质的调节剂，与细胞生长有关。它还可与中间纤维的其它蛋白相互作用。作为神经干细胞的标志物NES已被研究过。
外形
溶剂为含有0.02％叠氮化钠的磷酸盐缓冲盐水。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Chhagan Bihari et al.
Hepatology (Baltimore, Md.), 64(4), 1273-1288 (2016-08-04)
Bone marrow (BM) is a reservoir for immune and hematopoietic cells and critical for tissue repair and regeneration. All of these functions are severely altered in cirrhosis. We investigated the cellular and functional state of BM in cirrhosis patients. We
Sandra Pinho et al.
The Journal of experimental medicine, 210(7), 1351-1367 (2013-06-19)
The intermediate filament protein Nestin labels populations of stem/progenitor cells, including self-renewing mesenchymal stem cells (MSCs), a major constituent of the hematopoietic stem cell (HSC) niche. However, the intracellular location of Nestin prevents its use for prospective live cell isolation.
Chhagan Bihari et al.
Hepatology communications, 2(9), 1095-1110 (2018-09-12)
Bone loss is common in advanced cirrhosis, although the precise mechanisms underlying bone loss in cirrhosis are unknown. We studied the profile and functionality of bone-forming cells and bone-building proteins in bone marrow (BM) of individuals with cirrhosis (n =
Nianping Zhang et al.
International journal of molecular medicine, 40(3), 814-824 (2017-07-18)
Pluripotent stem cells (PSCs) are regarded as potential sources that provide specific neural cells for cell therapy in some nervous system diseases. However, the mechanisms underlying the neural differentiation of PSCs remain largely unknown. MicroRNAs (miRNAs or miRs) are a class of
Y Chen et al.
Osteoarthritis and cartilage, 23(10), 1728-1735 (2015-06-02)
Osteoarthritis (OA) is a progressive joint disorder. To date, there is not effective medical therapy. Joint distraction has given us hope for slowing down the OA progression. In this study, we investigated the benefits of joint distraction in OA rat
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