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Merck
CN

N5504

萘甲唑林 盐酸盐

别名:

2-(1-萘基甲基)咪唑啉 盐酸盐

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关于此项目

经验公式(希尔记法):
C14H14N2 · HCl
化学文摘社编号:
分子量:
246.74
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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表单

powder

质量水平

创始人

Allergan

SMILES字符串

Cl.C1CN=C(Cc2cccc3ccccc23)N1

InChI

1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

InChI key

DJDFFEBSKJCGHC-UHFFFAOYSA-N

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生化/生理作用

α-肾上腺素受体激动剂;咪唑啉受体激动剂;血管收缩剂。
盐酸萘甲唑啉是一种拟交感神经药。它也被认为是一种结膜减充血剂。

特点和优势

该化合物由Allergan开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Robert Fuchs et al.
Experimental cell research, 317(20), 2969-2980 (2011-08-20)
Even though the erythroleukemia cell lines K562 and HEL do not express α1-adrenoceptors, some α1-adrenergic drugs influence both survival and differentiation of these cell lines. Since Ca2+ is closely related to cellular homeostasis, we examined the capacity of α1-adrenergic drugs
Shizhong Zhu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 98, 142-147 (2012-09-22)
The fluorescence and ultraviolet spectroscopy were explored to study the interaction between Naphazoline hydrochloride (Naphcon) and bovine serum albumin (BSA) at three different temperatures (292, 301, and 310 K) under imitated physiological conditions. The quenching mechanism of BSA by Naphacon
Yuriko Nagane et al.
Muscle & nerve, 44(1), 41-44 (2011-04-15)
When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. Sixty MG patients with blepharoptosis (32 with
Nan-Nan Wang et al.
Luminescence : the journal of biological and chemical luminescence, 24(3), 178-182 (2009-03-03)
A sensitive and simple flow-injection chemiluminescence (FI-CL) method, which was based on the CL intensity generated from the redoxreaction of potassium permanganate (KMnO4)-formaldehyde in vitriol (H2SO4) medium, has been developed, validated and applied for the determination of naphazoline hydrochloride and
Robert Fuchs et al.
Experimental cell research, 317(16), 2239-2251 (2011-07-26)
Preliminary data showed that α1-adrenergic antagonists induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells. To test the hypothesis whether survival and differentiation of erythroleukemia cells are under control of α1-adrenergic signalling, we examined α1-adrenoceptor expression of

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