N6413
Anti-NR4A2 (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-HZF-3, Anti-NOT, Anti-NURR1, Anti-RNR1, Anti-TINUR
产品名称
Anti-NR4A2 (N-terminal) antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~70 kDa
species reactivity
human, mouse, rat
concentration
~1.5 mg/mL
technique(s)
indirect immunofluorescence: 4-8 μg/mL using 3T3 cells
western blot: 1-2 μg/mL using HEK-293T cell lysate expressing human NR4A2
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NR4A2(4929)
mouse ... Nr4a2(18227)
rat ... Nr4a2(54278)
Application
Anti-NR4A2 (N-terminal) antibody has been used in
- immunoblotting
- immunofluorescence
- western blotting
Biochem/physiol Actions
NR4A2 binds the NGFI-B (nerve growth factor-induced clone B) response element (NBRE) sequence (AAAGGTCA) as monomer. NR4A2 is induced by multiple extracellular signals, including fatty acids, stress, growth factors and neurotransmitters in a cell type specific manner. Hepatic expression of NR4A2 is induced by cAMP in response to glucagon and fasting. NR4A2 is essential for the differentiation of nigral dopaminergic neurons. NR4A2 mutations have been associated with disorders related to dopaminergic dysfunction, including Parkinson′s disease, schizophrenia.
Nuclear receptor subfamily 4 group A member 2 (NR4A2) acts as an activator of tyrosine hydroxylase. It is crucial for the process of DNA repair by melanocortin-1 receptor.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
NR4A2 (N-terminal) encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, includ
Nuclear receptor subfamily 4 group A member 2 (NR4A2) is part of transcriptional regulator subfamily, under the family of nuclear hormone receptors. It is a transcription factor expressed in the brain and T-cells.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
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Zhang L, et al.
PLoS ONE, 11(4), e0152931-e0152931 (2016)
Mutations in NR4A2 associated with familial Parkinson disease
Le W D, et al.
Nature Genetics, 33(1), 85-85 (2002)
Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease
Pearen M A and Muscat G E
Molecular Endocrinology, 24(10), 1891-1903 (2010)
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