N7758
纳洛酮盐酸盐二水合物 盐酸盐 二水合物
≥98% (TLC and titration), μ, κ, δ, and σ opioid receptor antagonist, powder
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关于此项目
经验公式（希尔记法）:
C19H21NO4 · HCl · 2H2O
化学文摘社编号:
分子量:
399.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
6260807
Assay:
≥98% (TLC and titration)
Form:
powder
产品名称
纳洛酮盐酸盐二水合物 盐酸盐 二水合物, ≥98% (TLC and titration), powder
Quality Segment
assay
≥98% (TLC and titration)
form
powder
optical activity
[α]25/D −178.6°, c = 2.5 in H2O(lit.)
color
white to off-white
solubility
ethanol: 3.3 mg/mL, H2O: 50 mg/mL
storage temp.
2-8°C
SMILES string
O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
InChI
1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
InChI key
TXMZWEASFRBVKY-IOQDSZRYSA-N
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)
Application
Naloxone hydrochloride dihydrate has been used in:
- isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
- as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
- as a reference neutral antagonist to define the maximum effect (Emax) of the system
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
光敏。
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves