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About This Item
经验公式（希尔记法）:
C19H21NO4 · HCl · 2H2O
CAS Number:
分子量:
399.87
Beilstein:
6260807
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (TLC and titration)
表单
powder
旋光性
[α]25/D −178.6°, c = 2.5 in H2O(lit.)
颜色
white to off-white
溶解性
ethanol: 3.3 mg/mL
H2O: 50 mg/mL
储存温度
2-8°C
SMILES字符串
O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
InChI
1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
InChI key
TXMZWEASFRBVKY-IOQDSZRYSA-N
基因信息
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)
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应用
Naloxone hydrochloride dihydrate has been used in:
- isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
- as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
- as a reference neutral antagonist to define the maximum effect (Emax) of the system
生化/生理作用
Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.
特点和优势
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
光敏。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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