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N9412

6β-Naltrexol hydrate

Name: 6β-Naltrexol hydrate
Brand: SIGMA

≥96% (HPLC), powder

别名:

(5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-morphinan-3,6,14-triol hydrate

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₅NO₄ · xH₂O

化学文摘社编号:

1034528-53-4

分子量:

343.42 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24724560

UNSPSC Code:

12352200

MDL number:

MFCD08277038

Assay:

≥96% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥96% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white

solubility

DMSO: ~12 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

[H]O[H].O[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC6CC6)c45

InChI

1S/C20H25NO4.H2O/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,14-15,18,22-24H,1-2,5-10H2;1H2/t14-,15-,18+,19+,20-;/m1./s1

InChI key

VHGGWFVHXKTOPK-CDHBEYIESA-N

说明

Biochem/physiol Actions

Neutral antagonist of the μ-opioid receptor. A reduction of withdrawal effects associated with neutral μ-opioid receptor antagonists may offer advantages in treating opioid overdose and addiction.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

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Lot/Batch Number

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商品

Opioid Receptors

We offers many products related to opioid receptors for your research needs.

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In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice.

Kirsten M Raehal et al.

The Journal of pharmacology and experimental therapeutics, 313(3), 1150-1162 (2005-02-18)

The mu-opioid receptor displays basal signaling activity, which seems to be enhanced by exposure to opioid agonists. This study assesses the in vivo pharmacology of the putative "neutral" antagonist 6beta-naltrexol in comparison to other ligands with varying efficacy, such as

Periaqueductal Gray and Rostromedial Tegmental Inhibitory Afferents to VTA Have Distinct Synaptic Plasticity and Opiate Sensitivity.

Robyn St Laurent et al.

Neuron, 106(4), 624-636 (2020-03-20)

The ventral tegmental area (VTA) is a major target of addictive drugs and receives multiple GABAergic projections originating outside the VTA. We describe differences in synaptic plasticity and behavior when optogenetically driving two opiate-sensitive GABAergic inputs to the VTA, the rostromedial

全球贸易项目编号

货号	GTIN
N9412-50MG	04061832557625
N9412-10MG	04061832557618