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O5889

Opipramol dihydrochloride

Name: Opipramol dihydrochloride
Brand: SIGMA

≥98% (HPLC), solid

别名:

4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol dihydrochloride

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关于此项目

经验公式（希尔记法）:

C₂₃H₂₉N₃O · 2HCl

化学文摘社编号:

909-39-7

分子量:

436.42

NACRES:

NA.77

PubChem Substance ID:

24724565

UNSPSC Code:

12352200

EC Number:

213-000-2

MDL number:

MFCD00941483

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

yellow

solubility

H₂O: ~24 mg/mL

SMILES string

Cl[H].Cl[H].OCCN1CCN(CCCN2c3ccccc3C=Cc4ccccc24)CC1

InChI

1S/C23H29N3O.2ClH/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26;;/h1-4,6-11,27H,5,12-19H2;2*1H

InChI key

DLTOEESOSYKJBK-UHFFFAOYSA-N

说明

General description

Opipramol acts as an antidepressant and is chemically similar to tricyclic antidepressants. It is an atypical anxiolytic and antidepressant drug. Opipramol mainly acts on sigma receptors. It is usually found to be much effective in depressive disorder. It has the ability to prevent histamine, serotonin, dopamine and alpha-1 adrenergic receptors.

Biochem/physiol Actions

σ₁/σ₂ opioid receptor agonist; an antagonist at D₂, 5HT₂ and H₁ receptors; atypical antidepressant, antipsychotic and anxiolytic

Atypical antidepressant, antipsychotic and anxiolytic

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H410

pcodes

P264 - P270 - P273 - P301 + P312 - P391 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000541127

0000268262

0000268261

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Neuropharmacology of the anxiolytic drug opipramol, a sigma site ligand.

W E Müller et al.

Pharmacopsychiatry, 37 Suppl 3, S189-S197 (2004-11-18)

Although opipramol is structurally related to imipramine, it does not represent a tricyclic antidepressant drug as it does not inhibit the neuronal uptake of norepinephrine and/or serotonin. Unlike imipramine it is a rather potent sigma ligand with modest subclass selectivity

Opipramol as nighttime medication.

Ulrich Leutgeb

Deutsches Arzteblatt international, 106(18), 321-321 (2009-06-24)

[Pharmacokinetics and relative bioavailability of opipramol in the new INSIDON--sustained release preparation].

E B Nilsson et al.

Fortschritte der Neurologie-Psychiatrie, 66 Suppl 1, S13-S16 (1999-01-29)

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全球贸易项目编号

货号	GTIN
O5889-25MG	04061832557731
O5889-100MG	04061832557724