跳转至内容
Merck
CN

O5889

Opipramol dihydrochloride

≥98% (HPLC), solid

别名:

4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol dihydrochloride

登录 查看组织和合同定价。

选择尺寸


关于此项目

经验公式(希尔记法):
C23H29N3O · 2HCl
化学文摘社编号:
分子量:
436.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
213-000-2
MDL number:
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助?我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

InChI key

DLTOEESOSYKJBK-UHFFFAOYSA-N

InChI

1S/C23H29N3O.2ClH/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26;;/h1-4,6-11,27H,5,12-19H2;2*1H

SMILES string

Cl[H].Cl[H].OCCN1CCN(CCCN2c3ccccc3C=Cc4ccccc24)CC1

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

yellow

solubility

H2O: ~24 mg/mL

Quality Level

General description

Opipramol acts as an antidepressant and is chemically similar to tricyclic antidepressants. It is an atypical anxiolytic and antidepressant drug. Opipramol mainly acts on sigma receptors. It is usually found to be much effective in depressive disorder. It has the ability to prevent histamine, serotonin, dopamine and alpha-1 adrenergic receptors.

Biochem/physiol Actions

σ12 opioid receptor agonist; an antagonist at D2, 5HT2 and H1 receptors; atypical antidepressant, antipsychotic and anxiolytic
Atypical antidepressant, antipsychotic and anxiolytic

pictograms

Exclamation markEnvironment

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

W E Müller et al.
Pharmacopsychiatry, 37 Suppl 3, S189-S197 (2004-11-18)
Although opipramol is structurally related to imipramine, it does not represent a tricyclic antidepressant drug as it does not inhibit the neuronal uptake of norepinephrine and/or serotonin. Unlike imipramine it is a rather potent sigma ligand with modest subclass selectivity
H-P Volz et al.
Pharmacopsychiatry, 37 Suppl 3, S214-S220 (2004-11-18)
So far, sigma-ligands have been investigated for several indications in human studies in functional diarrhea as a model of somatoform disorder (igmesine), depression (igmesine, opipramol), anxiety (opipramol and--in animal models--siramisine), schizophrenia (panamasine, SL 82.0715, rimcazole, DuP 734, BMY 14 802)
Opipramol as nighttime medication.
Ulrich Leutgeb
Deutsches Arzteblatt international, 106(18), 321-321 (2009-06-24)
[Pharmacokinetics and relative bioavailability of opipramol in the new INSIDON--sustained release preparation].
E B Nilsson et al.
Fortschritte der Neurologie-Psychiatrie, 66 Suppl 1, S13-S16 (1999-01-29)
[Opipramol (Insidon) in the treatment of somatoform disorders].
H J Freyberger et al.
Fortschritte der Neurologie-Psychiatrie, 66 Suppl 1, S25-S30 (1999-01-29)

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持