产品名称
Anti-OMP 兔抗, ~2 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~19 kDa
species reactivity
rat, mouse
concentration
~2 mg/mL
technique(s)
western blot: 0.5-1.0 μg/mL using rat brain (olfactory bulb) extract (S1 fraction).
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Omp(24612)
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Application
Anti-OMP antibody produced in rabbit has been used in immunohistochemistry.
Anti-OMP antibody produced in rabbit has been used in:
- immunoblotting
- double immunofluorescence
- staining
Biochem/physiol Actions
Olfactory marker protein (OMP) helps to modulate the formation and refinement of the olfactory glomerular map. OMP-deficient mice generated by gene targeting in embryonic stem (ES) cells are compromised in their ability to respond to odor stimuli. In the OMP-null mouse, in addition to reduced odorant response, the levels of neural tyrosine hydroxylase (TH) and neuropeptide cholecystokinin (CCK) are severely reduced. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Olfactory marker protein (OMP) is a phylogenetically conserved, 19kDa, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. The gene encoding OMP is localized on rat chromosome 1. OMP expression is initially detected in rat and mouse embryo during the last trimester of gestation and reaches adult levels at 2-4 weeks postnatally. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.
Immunogen
synthetic peptide corresponding to amino acids 119-137 located near the C-terminus of rat OMP conjugated to KLH.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
常规特殊物品
此项目有
Expression of CD36 by olfactory receptor cells and its abundance on the epithelial surface in mice
Lee S, et al.
PLoS ONE, 10(7), e0133412-e0133412 (2015)
Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements.
Biochemistry, 44(28), 9673-9679 (2005)
Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction.
Baldisseri DM,
Journal of Molecular Biology, 319(3), 823-837 (2002)
Violaine Mechin et al.
Animals : an open access journal from MDPI, 13(12) (2023-06-28)
Chemical communication in mammals is ensured by exchanging chemical signals through the vomeronasal organ (VNO) and its ability to detect pheromones. The alteration of this organ has been proven to impact animal life, participating in the onset of aggressive behaviors
Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons.
Proceedings of the National Academy of Sciences of the USA, 93(18), 9858-9863 (1996)
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