O8264
Anti-Orai1 兔抗
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
CRACM1, Calcium release-activated calcium channel protein 1, TMEM142A, Transmembrane protein 142A
产品名称
Anti-Orai1 兔抗, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~35 kDa (non-glycosylated)
antigen ~50 kDa (glycosylated)
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
western blot: 1-2 μg/mL using whole extract of human HEK-293T cells expressing ORAI1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ORAI1(84876)
mouse ... Orai1(109305)
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Application
Anti-ORAI1 antibody produced in rabbit has been used in immunohistochemistry and Western blotting.
Biochem/physiol Actions
ORAI calcium release-activated calcium modulator 1 (ORAI1) modulates Ca2+ entry into cells. The channel is activated by stromal interaction molecule-1 (STIM-1). Mutation in the gene encoding the protein has been linked to late-onset tubular aggregate myopathy and congenital miosis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
ORAI calcium release-activated calcium modulator 1 (ORAI1) is the pore-forming subunit of the Ca2+ release-activated (CRAC) channel. The protein possesses four predicted transmembrane domains and intracellular amino and carboxyl-terminal domains. The ORAI1 gene is localized on human chromosome 12q24.31.
Immunogen
synthetic peptide corresponding to amino acids 288-301 of human ORAI1, conjugated to KLH. The corresponding sequence differs by 2 amino acids in rat and mouse.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Yukari Endo et al.
Human molecular genetics, 24(3), 637-648 (2014-09-18)
The store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel is activated by diminished luminal Ca(2+) levels in the endoplasmic reticulum and sarcoplasmic reticulum (SR), and constitutes one of the major Ca(2+) entry pathways in various tissues. Tubular aggregates (TAs) are abnormal structures
Microdeletion of 12q24.31: Report of a Girl With Intellectual Disability, Stereotypies, Seizures and Facial Dysmorphisms
Orazio Palumbo
American Journal of Medical Genetics. Part A (2014)
Changbo Zheng et al.
Frontiers in pharmacology, 8, 222-222 (2017-05-11)
Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety
Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1
Renshan Sun
PLoS ONE (2016)
Antibody-Mediated Targeting of the Orai1 Calcium Channel Inhibits T Cell Function
Jennifer H. Cox
PLoS ONE (2013)
相关内容
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