ORAI calcium release-activated calcium modulator 1 (ORAI1) is the pore-forming subunit of the Ca²⁺ release-activated (CRAC) channel. The protein possesses four predicted transmembrane domains and intracellular amino and carboxyl-terminal domains. The ORAI1 gene is localized on human chromosome 12q24.31.

synthetic peptide corresponding to amino acids 288-301 of human ORAI1, conjugated to KLH. The corresponding sequence differs by 2 amino acids in rat and mouse.

Anti-ORAI1 antibody produced in rabbit has been used in immunohistochemistry and Western blotting.

ORAI calcium release-activated calcium modulator 1 (ORAI1) modulates Ca²⁺ entry into cells. The channel is activated by stromal interaction molecule-1 (STIM-1). Mutation in the gene encoding the protein has been linked to late-onset tubular aggregate myopathy and congenital miosis.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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