P0068
抗-p62/SQSTM1 （C-末端） 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
抗-泛素结合蛋白p62, 抗Sequestosome 1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoprecipitation (IP)
western blot
western blot
western blot
western blot
Species reactivity:
rat, mouse, human
Citations:
37
Technique(s):
immunoprecipitation (IP): 2-4 μg using whole extract of NIH-3T3 cells
western blot: 2-4 μg/mL using whole extracts of rat PC12 cells
western blot: 4-8 μg/mL using whole extracts of human A549 cells.
western blot: 2-4 μg/mL using whole extracts of rat PC12 cells
western blot: 4-8 μg/mL using whole extracts of human A549 cells.
Uniprot accession no.:
产品名称
抗-p62/SQSTM1 （C-末端） 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~62 kDa
species reactivity
rat, mouse, human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 2-4 μg using whole extract of NIH-3T3 cells
western blot: 2-4 μg/mL using whole extracts of rat PC12 cells
western blot: 4-8 μg/mL using whole extracts of human A549 cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SQSTM1(8878)
mouse ... Sqstm1(18412)
rat ... Sqstm1(113894)
Application
兔多克隆抗SQSTM1抗体已被用于：
- 用于免疫印迹
- 用于免疫沉淀
- 作为探针用于确定p62蛋白/sequestosome 1在自我吞噬等过程中的存在及其作用
Biochem/physiol Actions
p62蛋白（sequestosome 1，SQSTM1）是一种与泛素结合的多功能蛋白质。它是核因子kappa-B（NF-ΚB）信号通路的支架蛋白。SQSTM1还可调节细胞凋亡和自噬。该基因的突变导致了散发性和家族性佩吉特骨病。它还与蛋白质聚集疾病有关，如帕金森′病中的路易小体、阿尔茨海默′病中的神经原纤维缠结，以及亨廷顿蛋白聚集体。SQSTM1常见于含有多泛素化蛋白聚集体的包涵体中，这种聚集体在多种退行性疾病中累积。p62通过N端Phox和Bem1p（PB1）结构域聚合，并通过其C端泛素相关（UBA）结构域与多泛素化蛋白相互作用。p62是蛋白聚集体和自噬机制之间的连接体。
抗p62/SQSTM1抗体（C末端）可识别人、大鼠和小鼠p62/SQSTM1。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
General description
p62 蛋白/sequestosome 1(SQSTM1) 含有一个NH2末端Phox和Bem1p （PB1）结构域、一个ZZ型锌指结构域、一个含有假定磷酸化位点的Pro -Glu-Ser-Thr(PEST)结构域，以及一个COOH末端泛素相关结构域。SQSTM1定位于人染色体5q35.3。
Physical form
溶于含有15 mM叠氮化钠的0.01 M磷酸盐缓冲液（pH 7.4）。
Preparation Note
若需连续使用，可在2-8 °C下保存最长一个月。若需延长储存时间，可将溶液分装并冷冻。不建议反复冻融。如果长期储存时出现轻微浑浊，请在使用前通过离心澄清溶液。若工作稀释样品在12小时内未使用完，则应丢弃。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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