P0076

抗-PINK1 兔抗

Name: 抗-PINK1 兔抗
Brand: SIGMA

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

抗-BRPK, 抗-PARK6, 抗-PTEN-诱导的假定激酶蛋白1, 抗-丝氨酸/苏氨酸蛋白激酶PINK1，线粒体前体

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD08064431

Conjugate:

unconjugated

Clone:

polyclonal

Application:

western blot

Species reactivity:

mouse (predicted), human, rat (predicted)

Citations:

Technique(s):

western blot: 1-2 μg/mL using HEK-293T cell lysate expressign human PINK1

Uniprot accession no.:

Q9BXM7

主要文件

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产品名称

抗-PINK1 兔抗, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~60 kDa

species reactivity

mouse (predicted), human, rat (predicted)

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 1-2 μg/mL using HEK-293T cell lysate expressign human PINK1

UniProt accession no.

Q9BXM7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... PINK1(65018)
mouse ... Pink1(68943)
rat ... Pink1(298575)

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Application

兔抗PINK1抗体已被用于免疫印迹。

Biochem/physiol Actions

PINK1（PTEN诱导的推定激酶1，也称为PARK6和BRPK）已被确定与家族性帕金森病（PD）的常染色体隐性形式有关。定位于线粒体的PINK1保护细胞免受应激诱导的线粒体功能障碍。已发现野生型PINK1的过表达可保护神经元免受应激诱导的线粒体功能障碍和细胞凋亡。果蝇的遗传研究表明，PINK1在影响线粒体形态的共同途径中作用于Parkin的上游。已显示PINK1活性可在体外和体内保护小鼠原代神经元免受多巴胺能神经毒素MPTP（1-甲基-4-苯基吡啶（MPP+）/1-甲基-4-苯基-1，2，3，6-四氢吡啶）的侵害。这种保护活性需要PINK1激酶活性，因为与家族性PD连接的PINK1 G309D突变体或激酶死亡的突变体K219M不具有保护作用。PINK1已被证明可裂解并定位于线粒体，以响应体外增强的蛋白酶体应激，并与PD脑中加工的PINK1蛋白表达增加相关。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

PINK1是一种Ser/Thr激酶，已定位于线粒体，并被认为可以保护细胞免受应激诱导的线粒体功能障碍。

PTEN诱导的推定激酶1（PINK1）是在线粒体中表达的丝氨酸/苏氨酸激酶。它包含一个N端线粒体靶向基序和一个与Ca2+/钙调蛋白家族的丝氨酸/苏氨酸激酶同源的高度保守的激酶结构域。

Physical form

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

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PM2.5 increases susceptibility to acute exacerbation of COPD via NOX4/Nrf2 redox imbalance-mediated mitophagy.

Fan, et al.

Redox Biology, 59, 102587-102587 (2023)

PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury.

Ying Wang et al.

Cell death & disease, 9(11), 1113-1113 (2018-11-06)

Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of selective autophagy that removes damaged or dysfunctional mitochondria to maintain cellular homeostasis.

Transcriptome Highlights Cannabinol Modulation of Mitophagy in a Parkinson's Disease In Vitro Model.

Agnese Gugliandolo et al.

Biomolecules, 13(8) (2023-08-26)

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates, known as Lewy bodies. It is known that mitochondria dysfunctions, including impaired localization, transport and mitophagy

PINK1 protein in normal human brain and Parkinson's disease

Gandhi S, et al.

Brain, 129(7), 1720-1731 (2006)

Melatonin Alleviates Lipopolysaccharide-Induced Endometritis by Inhibiting the Activation of NLRP3 Inflammasome through Autophagy.

Yujin Gao et al.

Animals : an open access journal from MDPI, 13(15) (2023-08-12)

Bovine endometritis is characterized by reduced milk production and high rates of infertility. Prior research has indicated that melatonin may possess anti-inflammatory and antioxidant properties that can counteract the progression of inflammatory diseases. In this research, we attempted to elucidate

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抗-PINK1 兔抗

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

选择尺寸

关于此项目

主要文件

属性

产品名称

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

enhanced validation

concentration

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Application

Biochem/physiol Actions

Disclaimer

General description

Physical form

安全信息

存储类别

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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