P0076
抗-PINK1 兔抗
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
抗-BRPK, 抗-PARK6, 抗-PTEN-诱导的假定激酶蛋白1, 抗-丝氨酸/苏氨酸蛋白激酶PINK1，线粒体前体
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~60 kDa
species reactivity
mouse (predicted), human, rat (predicted)
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
western blot: 1-2 μg/mL using HEK-293T cell lysate expressign human PINK1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PINK1(65018)
mouse ... Pink1(68943)
rat ... Pink1(298575)
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General description
PINK1是一种Ser/Thr激酶，已定位于线粒体，并被认为可以保护细胞免受应激诱导的线粒体功能障碍。
PTEN诱导的推定激酶1（PINK1）是在线粒体中表达的丝氨酸/苏氨酸激酶。它包含一个N端线粒体靶向基序和一个与Ca2+/钙调蛋白家族的丝氨酸/苏氨酸激酶同源的高度保守的激酶结构域。
Application
兔抗PINK1抗体已被用于免疫印迹。
Biochem/physiol Actions
PINK1（PTEN诱导的推定激酶1，也称为PARK6和BRPK）已被确定与家族性帕金森病（PD）的常染色体隐性形式有关。定位于线粒体的PINK1保护细胞免受应激诱导的线粒体功能障碍。已发现野生型PINK1的过表达可保护神经元免受应激诱导的线粒体功能障碍和细胞凋亡。果蝇的遗传研究表明，PINK1在影响线粒体形态的共同途径中作用于Parkin的上游。已显示PINK1活性可在体外和体内保护小鼠原代神经元免受多巴胺能神经毒素MPTP（1-甲基-4-苯基吡啶（MPP+）/1-甲基-4-苯基-1，2，3，6-四氢吡啶）的侵害。这种保护活性需要PINK1激酶活性，因为与家族性PD连接的PINK1 G309D突变体或激酶死亡的突变体K219M不具有保护作用。PINK1已被证明可裂解并定位于线粒体，以响应体外增强的蛋白酶体应激，并与PD脑中加工的PINK1蛋白表达增加相关。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
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Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein aggregates, known as Lewy bodies. It is known that mitochondria dysfunctions, including impaired localization, transport and mitophagy
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Cell death & disease, 9(11), 1113-1113 (2018-11-06)
Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of selective autophagy that removes damaged or dysfunctional mitochondria to maintain cellular homeostasis.
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
Beilina A, et al.
Proceedings of the National Academy of Sciences of the USA, 102(16), 5703-5708 (2005)
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