P1998
抗 周脂素 A 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
Anti-FPLD4, Anti-PERI, Anti-PLIN
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB CL
Citations:
26
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~62 kDa
species reactivity
mouse, human
technique(s)
indirect immunofluorescence: 5-10 μg/mL using differentiated mouse NIH3T3-L1 cells., western blot (chemiluminescent): 1-2 μg/mL using whole extract of differentiated mouse NIH3T3-L1 cells
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PLIN(5346)
mouse ... Plin(103968)
rat ... Plin(25629)
General description
脂被蛋白是白色和褐色脂肪细胞内用于贮存中性脂质的脂滴的表面蛋白。肾上腺皮质、卵巢中的类固醇生成细胞和睾丸间质细胞存在内含胆固醇酯的较小脂滴，其表面也包被少量的脂被蛋白。脂滴包被蛋白具有多种同工型，这是由于差异剪接事件引起的。脂滴包被蛋白A在脂肪细胞和类固醇生成细胞中含量最高。脂滴包被蛋白B是脂肪细胞中的次要形式。类固醇生成细胞选择性表达脂滴包被蛋白C和D。
Immunogen
与人脂滴包被蛋白A的氨基酸残基492-505相对应的合成肽，其中C-末端添加了与KLH偶联的半胱氨酸。相应的序列在小鼠和大鼠中相差一个残基。
Application
兔体内产生的抗脂滴包被蛋白A抗体也可用于：
- 间接免疫荧光
- 免疫印迹
- 免疫组织化学
Biochem/physiol Actions
脂滴包被蛋白可作为分子开关，通过保护甘油三酯防止其水解而抑制基础的脂肪分解，参与调控脂肪细胞的甘油三酯贮存。脂滴包被蛋白还通过激素敏感脂肪酶（HSL）和非HSL来增强环磷酸腺苷（cAMP）依赖蛋白激酶（PKA）激活的脂肪分解。脂被蛋白敲除小鼠的脂肪组织减少，并且能抵制饮食导致的肥胖。它们的脂质贮存脂滴包被未被PKA磷酸化的脂肪分化相关蛋白（ADRP，adipophilin）。
Physical form
溶于含有15 mM 氮化钠的0.01M磷酸盐缓冲盐水（pH 7.4）。
Disclaimer
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存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
低风险生物材料
常规特殊物品
此项目有
Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells
Servetnick DA, et al.
The Journal of Biological Chemistry, 270(28), 16970-16973 (1995)
Jörn Söhle et al.
PloS one, 7(2), e31193-e31193 (2012-03-03)
Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its associated diseases. One prerequisite for advances in this field is the identification of genes involved in
Yi-Shiuan Tzeng et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 33(4), 679-690 (2017-11-10)
Bone and bone marrow serve as an imperative ecosystem to various types of cells participating in critical body functions. The chemokine Cxcl12, also known as stromal cell-derived factor 1 (Sdf1), is one of the communication factors in the marrow microenvironment
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation
Sztalryd C, et al.
The Journal of Cell Biology, 161(6), 1093-1103 (2003)
Hui Zhang et al.
Circulation research, 118(2), 254-265 (2015-12-15)
Unraveling the developmental origin of cardiac fat could offer important implications for the treatment of cardiovascular disease. The recent identification of the mesothelial source of epicardial fat tissues reveals a heterogeneous origin of adipocytes in the adult heart. However, the
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