产品名称
抗 周脂素 A 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~62 kDa
species reactivity
mouse, human
technique(s)
indirect immunofluorescence: 5-10 μg/mL using differentiated mouse NIH3T3-L1 cells.
western blot (chemiluminescent): 1-2 μg/mL using whole extract of differentiated mouse NIH3T3-L1 cells
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PLIN(5346)
mouse ... Plin(103968)
rat ... Plin(25629)
Application
兔体内产生的抗脂滴包被蛋白A抗体也可用于：
- 间接免疫荧光
- 免疫印迹
- 免疫组织化学
Biochem/physiol Actions
脂滴包被蛋白可作为分子开关，通过保护甘油三酯防止其水解而抑制基础的脂肪分解，参与调控脂肪细胞的甘油三酯贮存。脂滴包被蛋白还通过激素敏感脂肪酶（HSL）和非HSL来增强环磷酸腺苷（cAMP）依赖蛋白激酶（PKA）激活的脂肪分解。脂被蛋白敲除小鼠的脂肪组织减少，并且能抵制饮食导致的肥胖。它们的脂质贮存脂滴包被未被PKA磷酸化的脂肪分化相关蛋白（ADRP，adipophilin）。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
脂被蛋白是白色和褐色脂肪细胞内用于贮存中性脂质的脂滴的表面蛋白。肾上腺皮质、卵巢中的类固醇生成细胞和睾丸间质细胞存在内含胆固醇酯的较小脂滴，其表面也包被少量的脂被蛋白。脂滴包被蛋白具有多种同工型，这是由于差异剪接事件引起的。脂滴包被蛋白A在脂肪细胞和类固醇生成细胞中含量最高。脂滴包被蛋白B是脂肪细胞中的次要形式。类固醇生成细胞选择性表达脂滴包被蛋白C和D。
Immunogen
与人脂滴包被蛋白A的氨基酸残基492-505相对应的合成肽，其中C-末端添加了与KLH偶联的半胱氨酸。相应的序列在小鼠和大鼠中相差一个残基。
Physical form
溶于含有15 mM 氮化钠的0.01M磷酸盐缓冲盐水（pH 7.4）。
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存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
常规特殊物品
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