P2318
抗 假单胞菌外毒素 A 兔抗
whole antiserum
别名:
Anti-ETA
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
DB, ELISA (i)
Citations:
19
biological source
rabbit
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
species reactivity
(Pseudomonas aeruginosa)
technique(s)
dot blot: 1:20,000, indirect ELISA: 1:250,000
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
Pseudomonas aeruginosa PAO1 ... toxA(877850)
General description
可与假单胞菌外毒素A发生反应，但对葡萄球菌肠毒素A、霍乱毒素和葡萄球菌肠毒素B无反应。该产品尚未检测过对活性假单胞菌外毒素A的中和效力。
Immunogen
来源于铜绿假单胞菌的外毒素A。
Application
兔抗假单胞菌外毒素A抗体可用于：
- 血清融合毒素的体外稳定性分析
- 构建靶向表皮生长因子受体（EGFR）的毒素，以研究其对转染人EGFR的Swiss小鼠胚胎NIH-3T3细胞的毒性
- 测定血清中免疫毒素的体内半衰期
抗假单胞菌外毒素A抗体可用于融合毒素的体外血清稳定性和靶向毒素的结合研究。
Biochem/physiol Actions
铜绿假单胞菌外毒素A由铜绿假单胞菌分泌，具有较强的细胞毒性作用。外毒素A通过受体介导的内吞作用进入细胞，转运到细胞质，通过ADP核糖化因子2抑制蛋白质合成。嵌合外毒素A在各种疾病的基因治疗和可能的癌症治疗中都有应用。
Physical form
本产品是含有15 mM 叠氮化钠防腐剂的液体。
Preparation Note
如需连续使用，可在2-8 °C保存至多一月。对于更长期的存储，可对溶液进行等分并冷冻保存。不建议反复冻融。不建议在无霜冰箱中储存。如果长期储存后发生轻微浑浊，请在使用前通过离心澄清溶液。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
动植物来源生物产品
常规特殊物品
此项目有
Nihal Karakaş et al.
International journal of molecular medicine, 48(1) (2021-06-04)
Glioblastomas (GBMs) are refractory to current treatments and novel therapeutic approaches need to be explored. Pro‑apoptotic tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) is tumor‑specific and has been shown to induce apoptosis and subsequently kill GBM cells. However, approximately 50% of
Yi-Fan Zhang et al.
mAbs, 9(3), 419-429 (2017-02-07)
Rabbit monoclonal antibodies (RabMAbs) can recognize diverse epitopes, including those poorly immunogenic in mice and humans. However, there have been only a few reports on RabMAb humanization, an important antibody engineering step usually done before clinical applications are investigated. To
Mark Kowalski et al.
Drug design, development and therapy, 4, 313-320 (2010-12-15)
A Phase I dose-escalation study was performed to determine the maximum tolerated dose (MTD) of the immunotoxin VB4-845 in patients with nonmuscle-invasive bladder cancer (NMIBC) refractory to or intolerant of bacillus Calmette-Guerin (BCG). Secondary objectives included evaluation of the safety
Alexander N Wein et al.
Journal of medicinal chemistry, 55(18), 7998-8006 (2012-09-08)
Protective antigen (PA), lethal factor, and edema factor, the protein toxins of Bacillus anthracis , are among its most important virulence factors and play a key role in infection. We performed a virtual ligand screen of a library of 10000
Alexander Weng et al.
Molecular oncology, 6(3), 323-332 (2012-02-09)
Tumor-targeting protein toxins are composed of a toxic enzyme coupled to a specific cell binding domain that targets cancer-associated antigens. The anti-tumor treatment by targeted toxins is accompanied by dose-limiting side effects. The future prospects of targeted toxins for therapeutic
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持