P2607
PRE-084
σ1 opioid receptor agonist, solid
别名:
2-（4-吗啉乙基）-1-苯基环己烷羧酸盐酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C19H27NO3 · HCl
分子量:
353.88
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
PRE-084, solid
form
solid
SMILES string
Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3
InChI
1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H
InChI key
QUJWFJNHTBKCLU-UHFFFAOYSA-N
description
Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet.
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
solubility
H2O: ≤24 mg/mL
Quality Level
Gene Information
human ... OPRS1(10280)
rat ... Oprs1(29336), Slc6a3(24898)
Biochem/physiol Actions
PRE-084一种有效且高度选择性的σ1 阿片受体激动剂。它在栓塞性中风可提供神经保护。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yuriko Kimura et al.
PloS one, 8(10), e75760-e75760 (2013-10-12)
Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (CNS). For that, it is considered as an
Li-Li Ji et al.
Molecular medicine reports, 16(4), 4987-4993 (2017-08-10)
Accumulating evidence has demonstrated that the σ-1 receptor (σ‑1R) possesses neuroprotective effects and is a potential novel therapeutic target for certain psychiatric diseases, including post‑traumatic stress disorder (PTSD) accompanied with anxiety disorder. It has been reported that σ‑1R agonist treatment
Judit Hodrea et al.
International journal of molecular sciences, 24(14) (2023-07-29)
Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor of the disease and it can be caused by fibrotic-like changes in the trabecular meshwork (TM) such as increased
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
Allahtavakoli M and Jarrott B
Brain Research Bulletin, 85(3-4), 219-224 (2011)
Stefanie Vogler et al.
Neuroscience letters, 610, 13-18 (2015-10-27)
Water accumulation in retinal glial (Müller) and neuronal cells resulting in cellular swelling contributes to the development of retinal edema and neurodegeneration. Sigma (σ) receptor activation is known to have neuroprotective effects in the retina. Here, we show that the
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