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P2607

PRE-084

Name: PRE-084
Brand: SIGMA

σ1 opioid receptor agonist, solid

别名:

2-（4-吗啉乙基）-1-苯基环己烷羧酸盐酸盐

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₇NO₃ · HCl

分子量:

353.88

UNSPSC Code:

12352200

PubChem Substance ID:

24278627

NACRES:

NA.77

MDL number:

MFCD00673883

Form:

solid

Quality level:

200

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产品名称

PRE-084, solid

description

Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet.

Quality Level

200

form

solid

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

solubility

H₂O: ≤24 mg/mL

SMILES string

Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3

InChI

1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H

InChI key

QUJWFJNHTBKCLU-UHFFFAOYSA-N

Gene Information

human ... OPRS1(10280)
rat ... Oprs1(29336), Slc6a3(24898)

Biochem/physiol Actions

PRE-084一种有效且高度选择性的σ1 阿片受体激动剂。它在栓塞性中风可提供神经保护。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signaling.

Yuriko Kimura et al.

PloS one, 8(10), e75760-e75760 (2013-10-12)

Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (CNS). For that, it is considered as an

Sigma-1 Receptor Agonist Fluvoxamine Ameliorates Fibrotic Response of Trabecular Meshwork Cells.

Judit Hodrea et al.

International journal of molecular sciences, 24(14) (2023-07-29)

Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor of the disease and it can be caused by fibrotic-like changes in the trabecular meshwork (TM) such as increased

Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats

Allahtavakoli M and Jarrott B

Brain Research Bulletin, 85(3-4), 219-224 (2011)

Sigma-1 receptor activation ameliorates anxiety-like behavior through NR2A-CREB-BDNF signaling pathway in a rat model submitted to single-prolonged stress.

Li-Li Ji et al.

Molecular medicine reports, 16(4), 4987-4993 (2017-08-10)

Accumulating evidence has demonstrated that the σ-1 receptor (σ‑1R) possesses neuroprotective effects and is a potential novel therapeutic target for certain psychiatric diseases, including post‑traumatic stress disorder (PTSD) accompanied with anxiety disorder. It has been reported that σ‑1R agonist treatment

Cyproheptadine Regulates Pyramidal Neuron Excitability in Mouse Medial Prefrontal Cortex.

Yan-Lin He et al.

Neuroscience bulletin, 34(5), 759-768 (2018-04-20)

Cyproheptadine (CPH), a first-generation antihistamine, enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway. In this study, we aimed to determine the effects of CPH on neuronal excitability in

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全球贸易项目编号

货号	GTIN
P2607-10MG	04061834364092
P2607-50MG	04061832557861

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