P2607
PRE-084
σ1 opioid receptor agonist, solid
别名:
2-（4-吗啉乙基）-1-苯基环己烷羧酸盐酸盐
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关于此项目
经验公式（希尔记法）:
C19H27NO3 · HCl
分子量:
353.88
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
PRE-084, solid
描述
Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet.
质量水平
表单
solid
drug control
Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
溶解性
H2O: ≤24 mg/mL
SMILES字符串
Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3
InChI
1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H
InChI key
QUJWFJNHTBKCLU-UHFFFAOYSA-N
基因信息
human ... OPRS1(10280)
rat ... Oprs1(29336), Slc6a3(24898)
生化/生理作用
PRE-084一种有效且高度选择性的σ1 阿片受体激动剂。它在栓塞性中风可提供神经保护。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
Allahtavakoli M and Jarrott B
Brain Research Bulletin, 85(3-4), 219-224 (2011)
T Maurice et al.
British journal of pharmacology, 127(2), 335-342 (1999-06-29)
1. Sigma (sigma) receptor ligands were previously reported to alleviate learning and memory impairments on several pharmacological and pathological rodent models of amnesia. Such effect was demonstrated as involving the sigma1 subtype of sigma receptor. 2. In this study, we
Judit Hodrea et al.
International journal of molecular sciences, 24(14) (2023-07-29)
Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor of the disease and it can be caused by fibrotic-like changes in the trabecular meshwork (TM) such as increased
Stefanie Vogler et al.
Neuroscience letters, 610, 13-18 (2015-10-27)
Water accumulation in retinal glial (Müller) and neuronal cells resulting in cellular swelling contributes to the development of retinal edema and neurodegeneration. Sigma (σ) receptor activation is known to have neuroprotective effects in the retina. Here, we show that the
Li-Li Ji et al.
Molecular medicine reports, 16(4), 4987-4993 (2017-08-10)
Accumulating evidence has demonstrated that the σ-1 receptor (σ‑1R) possesses neuroprotective effects and is a potential novel therapeutic target for certain psychiatric diseases, including post‑traumatic stress disorder (PTSD) accompanied with anxiety disorder. It has been reported that σ‑1R agonist treatment
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