P2860
抗PSF单抗 小鼠抗
clone B92, purified from hybridoma cell culture
别名:
Mouse Anti-Polypyrimidine tract-binding protein-associated splicing factor
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
B92, monoclonal
表单
buffered aqueous solution
种属反应性
mouse, human
包装
antibody small pack of 25 μL
浓度
~2 mg/mL
技术
immunocytochemistry: suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
radioimmunoassay: suitable using cells
western blot: 2-4 μg/mL using whole extract of cultured HeLa cells
同位素/亚型
IgG1
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TAP1(6890)
一般描述
单克隆抗PSF（小鼠IgG1同种型）来源于小鼠骨髓瘤细胞和以小鼠骨髓基质细胞系裂解液免疫的C57BL/6J小鼠脾细胞融合而产生的B92杂交瘤细胞。聚嘧啶束结合蛋白相关剪接因子（PSF）是一种广泛存在的细胞核基质蛋白。它的特征是具有两个共有的RNA结合结构域和一个富含脯氨酸和谷氨酰胺残基的异常氨基末端。
免疫原
小鼠骨髓基质细胞系裂解物。
生化/生理作用
聚嘧啶束结合蛋白相关剪接因子（PSF）在哺乳动物剪接体中起着关键作用。PSF也是pre-mRNA剪接和转录所必需的。PSF的受限表达表明，它参与控制神经元分化和成熟的特定阶段发生的神经元特异性剪接事件。与PSF特异性反应的单克隆抗体是PSF分子鉴定和功能活性表征的有用工具。
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
制备说明
通过对生物反应器中的杂交瘤细胞培养物上清液提纯获得。
免责声明
除非我们的目录或随附于产品的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Christopher A Yarosh et al.
Nucleic acids research, 43(18), 9006-9016 (2015-08-12)
PSF (a.k.a. SFPQ) is a ubiquitously expressed, essential nuclear protein with important roles in DNA damage repair and RNA biogenesis. In stimulated T cells, PSF binds to and suppresses the inclusion of CD45 exon 4 in the final mRNA; however
Heike J Wobst et al.
Frontiers in molecular neuroscience, 10, 46-46 (2017-03-14)
Mutations in the gene
Wen Shen et al.
Nucleic acids research, 46(5), 2204-2217 (2018-02-02)
We reported previously that a 2' fluoro-modified (2' F) phosphorothioate (PS) antisense oligonucleotides (ASOs) with 5-10-5 gapmer configuration interacted with proteins from Drosophila behavior/human splicing (DBHS) family with higher affinity than PS-ASOs modified with 2'-O-(2-methoxyethyl) (2' MOE) or 2',4'-constrained 2'-O-ethyl
Chungoo Park et al.
Scientific reports, 7(1), 11211-11211 (2017-09-13)
Rbfox RNA-binding proteins play important roles in the regulation of alternative pre-mRNA splicing, but their role in other gene regulatory mechanisms is not well understood. Here, we show that Rbfox2 is a novel constituent of cytoplasmic stress granules, the translational
Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB
Meissner M, et al.
Journal of Cellular Biochemistry, 76(4), 559-566 (2000)
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