P2860
抗PSF单抗 小鼠抗
clone B92, purified from hybridoma cell culture
别名:
Mouse Anti-Polypyrimidine tract-binding protein-associated splicing factor
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关于此项目
Conjugate:
unconjugated
Clone:
B92, monoclonal
Application:
ARR, ICC, IHC (f), IP, RIA, WB
Citations:
37
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
B92, monoclonal
form
buffered aqueous solution
species reactivity
mouse, human
packaging
antibody small pack of 25 μL
concentration
~2 mg/mL
technique(s)
immunocytochemistry: suitable, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, microarray: suitable, radioimmunoassay: suitable using cells, western blot: 2-4 μg/mL using whole extract of cultured HeLa cells
isotype
IgG1
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TAP1(6890)
General description
单克隆抗PSF（小鼠IgG1同种型）来源于小鼠骨髓瘤细胞和以小鼠骨髓基质细胞系裂解液免疫的C57BL/6J小鼠脾细胞融合而产生的B92杂交瘤细胞。聚嘧啶束结合蛋白相关剪接因子（PSF）是一种广泛存在的细胞核基质蛋白。它的特征是具有两个共有的RNA结合结构域和一个富含脯氨酸和谷氨酰胺残基的异常氨基末端。
Immunogen
小鼠骨髓基质细胞系裂解物。
Biochem/physiol Actions
聚嘧啶束结合蛋白相关剪接因子（PSF）在哺乳动物剪接体中起着关键作用。PSF也是pre-mRNA剪接和转录所必需的。PSF的受限表达表明，它参与控制神经元分化和成熟的特定阶段发生的神经元特异性剪接事件。与PSF特异性反应的单克隆抗体是PSF分子鉴定和功能活性表征的有用工具。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Preparation Note
通过对生物反应器中的杂交瘤细胞培养物上清液提纯获得。
Disclaimer
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
常规特殊物品
此项目有
Christopher A Yarosh et al.
Nucleic acids research, 43(18), 9006-9016 (2015-08-12)
PSF (a.k.a. SFPQ) is a ubiquitously expressed, essential nuclear protein with important roles in DNA damage repair and RNA biogenesis. In stimulated T cells, PSF binds to and suppresses the inclusion of CD45 exon 4 in the final mRNA; however
Heike J Wobst et al.
Frontiers in molecular neuroscience, 10, 46-46 (2017-03-14)
Mutations in the gene
Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways
Wang T, et al.
Neurobiology of Aging, 36(1), 527-535 (2015)
Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing
Morozumi Y, et al.
Nucleic Acids Research, 40(7), 3031-3041 (2011)
Feng Chi et al.
PloS one, 7(4), e35862-e35862 (2012-04-27)
IbeA-induced NF-κB signaling through its primary receptor vimentin as well as its co-receptor PSF is required for meningitic E. coli K1 penetration and leukocyte transmigration across the blood-brain barrier (BBB), which are the hallmarks of bacterial meningitis. However, it is
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