P4871
抗-嘌呤能受体P2Y12 兔抗
affinity isolated antibody, lyophilized powder
别名:
Anti-ADPG-R, Anti-BDPLT8, Anti-HORK3, Anti-P2T(AC), Anti-P2Y(12)R, Anti-P2Y(AC), Anti-P2Y(ADP), Anti-P2Y(cyc), Anti-P2Y12
产品名称
抗-嘌呤能受体P2Y12 兔抗, affinity isolated antibody, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, mouse, rat
technique(s)
immunohistochemistry: suitable using mouse brain sections
western blot: 1:200 using rat brain membranes or human platelets
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... P2RY12(64805)
mouse ... P2ry12(70839)
rat ... P2ry12(64803)
Immunogen
对应于人P2Y12的氨基酸残基125-142的肽。该表位在大鼠和小鼠中高度同源（18个残基中有16个是相同的）。
Physical form
从含有1％牛血清白蛋白和0.05％叠氮化钠的磷酸盐缓冲液（pH 7.4）中冻干。
Application
兔抗嘌呤能受体P2Y12抗体已用于蛋白质免疫印迹。
Biochem/physiol Actions
嘌呤能受体或血小板腺苷 5′-二磷酸 (ADP) 受体 P2Y12 参与 ADP 诱导的血小板聚集。该蛋白质的功能失调突变与出血性疾病有关。研究表明，P2Y12 受体缺陷小鼠表现出肿瘤转移减弱。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
嘌呤能受体或血小板腺苷5′-二磷酸 (ADP) 受体 P2Y12 是一种 G 蛋白偶联受体。编码它的基因位于人类染色体 3q25.1 上。
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Thomas H Smith et al.
The Journal of biological chemistry, 292(33), 13867-13878 (2017-06-28)
Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4
Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.
Lecchi A
Hamostaseologie (2016)
Expression and Localization of Purinergic P2Y12 Receptor in Human Nasal Mucosa
Hideaki Shirasaki
Allergology International (2013)
Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells
Hideaki Shirasaki
Allergology International (2014)
Supplementary Table 1. Sample demographics for participants included in genome-wide association analyses
Hypertension (2016)
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