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Merck
CN

P6126

(R)-(−)-去氧肾上腺素 盐酸盐

≥99% (titration), powder, α₁-adrenoceptor agonist

别名:

(R)-(−)-1-(3-羟基苯基)-2-甲氨基乙醇 盐酸盐, (R)-(−)-3-羟基-α-(甲氨基乙基)苄醇 盐酸盐

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关于此项目

线性分子式:
HOC6H4CH(CH2NHCH3)OH·HCl
化学文摘社编号:
分子量:
203.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-517-3
MDL number:
Beilstein/REAXYS Number:
4158948
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产品名称

(R)-(−)-去氧肾上腺素 盐酸盐, powder

InChI key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

InChI

1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

SMILES string

OC1=CC([C@H](CNC)O)=CC=C1.Cl

form

powder

mp

143-145 °C (lit.)

originator

Johnson & Johnson

Quality Level

Gene Information

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General description

(R)-(-)-去氧肾上腺素盐酸盐是一种肾上腺素能药,其作为 β-受体拟交感神经药。

Application

(R)-(-)-去氧肾上腺素盐酸盐已用于:
  • 心肌细胞和成纤维细胞的制备和培养
  • 刺激心肌条以测量 slice 收缩
  • 在原代心肌细胞培养中研究 Kruppel 样因子(KLF)对体内心肌肥大的影响
  • 评估胚胎干细胞(ESC)衍生的心肌细胞的药理反应
  • 从药理学上挽救早期胚胎致死性的 GATA(类胡萝卜素转录因子)结合蛋白 3(GATA3)空胚

Biochem/physiol Actions

α1-肾上腺素受体激动剂。

Features and Benefits

该化合物在受体分类和信号转导手册中α-肾上腺素能受体页面中进行了详细介绍。想要浏览手册的其他页面, 请单击此处
该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单, 请单击此处

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1B

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is (R)-(-)-Phenylephrine hydrochloride the same as L-Phenylephrine hydrochloride?

    (R)-(-)-Phenylephrine hydrochloride is also named l-Phenylephrine hydrochloride (lower case el) or Levophenylephrine hydrochloride.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1
Bhavsar PK, et al.
Journal of Cardiovascular Translational Research, 3(6), 688-695 (2010)
A myocardial slice culture model reveals alpha-1A-adrenergic receptor signaling in the human heart
Thomas RC, et al.
JACC. Basic to translational science, 1(3), 155-167 (2016)
Effect of basic fibroblast growth factor on cardiomyocyte differentiation from mouse embryonic stem cells.
Khezri S, et al.
Saudi Medical Journal, 28(2), 181-186 (2007)
Enantioselective synthesis of (R)-phenylephrine hydrochloride
Pandey RK, et al.
Tetrahedron Letters, 44(33), 6245-6246 (2003)
Kruppel-like factor 4 regulates pressure-induced cardiac hypertrophy
Liao X, et al.
Journal of Molecular and Cellular Cardiology, 49(2), 334-338 (2010)

商品

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

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