P6628
毛果芸香碱 硝酸盐
≥98% (HPLC), muscarinic acetylcholine receptor agonist, powder
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关于此项目
经验公式（希尔记法）:
C11H16N2O2 · HNO3
化学文摘社编号:
分子量:
271.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-723-7
MDL number:
Beilstein/REAXYS Number:
4171406
产品名称
毛果芸香碱 硝酸盐, ≥98% (HPLC)
InChI key
PRZXEPJJHQYOGF-GNAZCLTHSA-N
InChI
1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
SMILES string
O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
assay
≥98% (HPLC)
form
powder
optical activity
[α]25/D +83°, c = 10 in H2O(lit.)
color
white
solubility
H2O: 100 mg/mL
Quality Level
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
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Biochem/physiol Actions
非选择性毒蕈碱型乙酰胆碱受体激动剂。
非选择性毒蕈碱型乙酰胆碱受体激动剂；用于建立癫痫的实验模型。
Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.
Application
Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2
存储类别
5.1B - Oxidizing hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Different patterns of neuronal activation and neurodegeneration in the thalamus and cortex of epilepsy-resistant Proechimys rats versus Wistar rats after pilocarpine-induced protracted seizures
Andrioli A, et al.
Epilepsia, 50(4), 832-848 (2009)
Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats
Nie Z, et al.
American Journal of Respiratory Cell and Molecular Biology, 51(2), 251-261 (2014)
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
Manuela Mazzuferi et al.
Annals of neurology, 74(4), 560-568 (2013-05-21)
Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for epilepsy, because single target therapies are unlikely to provide both anticonvulsant and disease-modifying effects. A selection of epilepsy-related gene expression data sets were retrieved
Mi-Hyeon Jang et al.
Cell stem cell, 12(2), 215-223 (2013-02-12)
Adult neurogenesis, the process of generating mature neurons from adult neural stem cells, proceeds concurrently with ongoing neuronal circuit activity and is modulated by various physiological and pathological stimuli. The niche mechanism underlying the activity-dependent regulation of the sequential steps
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