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P8920

多聚-L-赖氨酸 溶液

0.1 % (w/v) in H2O

别名:

2-(4-氰基苯胺基)-4,6-二氯嘧啶, 4-[(4,6-二氯-2-嘧啶基)氨基]氰苯

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关于此项目

化学文摘社编号:
25988-63-0
UNSPSC Code:
41116121
eCl@ss:
32160406
NACRES:
NA.47
MDL number:
MFCD00165424
Biological source:
synthetic
Mol wt:
150,000-300,000
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biological source

synthetic

Quality Level

200

shelf life

Expiry date on the label.

mol wt

150,000-300,000

concentration

0.1 % (w/v) in H2O

color

colorless

application(s)

hematology
histology

storage temp.

room temp

SMILES string

N([C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)C(=O)[C@@H](N)CCCCN

InChI

1S/C18H38N6O4/c19-10-4-1-7-13(22)16(25)23-14(8-2-5-11-20)17(26)24-15(18(27)28)9-3-6-12-21/h13-15H,1-12,19-22H2,(H,23,25)(H,24,26)(H,27,28)/t13-,14-,15-/m0/s1

InChI key

WBSCNDJQPKSPII-KKUMJFAQSA-N

相关类别

Application

聚-L-赖氨酸溶液已用于将内皮细胞横截面附着到UV交联的PET膜框架玻片上。聚-L-赖氨酸涂覆的玻片用于放置用于免疫组化检测的组织切片。
聚-L-赖氨酸聚合物可用于促进细胞对固体底物的粘附、与甲氨蝶呤结合以增加药物转运、胰岛微囊化、细胞微囊化技术、微阵列玻片涂层和染色体制剂。 较低分子量的聚-L-赖氨酸（30000-70000）在溶液中粘度较低，但分子量较高的聚赖氨酸在每个分子中提供更多的附着位点。

Biochem/physiol Actions

聚-L-赖氨酸是一种非特异性的细胞附着因子，通过增强细胞膜负离子与培养基表面的静电相互作用，促进细胞对固体基质的粘附。 当其吸附到细胞培养表面时，聚-L-赖氨酸的作用是增加可用于细胞结合的带正电荷位点的数量。 对于可降解聚-L-赖氨酸的细胞，应采用聚-D-赖氨酸作为附着因子。

Preparation Note

该产品以0.10％（w/v）水溶液形式提供的。用该溶液进行涂覆的玻片应当随后进行一步5分钟的孵育并在室温对其进行干燥。 涂覆的玻片在免收灰尘的保护下可稳定一年。

Other Notes

聚-L-赖氨酸是一种带正电荷的氨基酸聚合物，每个赖氨酸残基约有一个HBr。 氢溴酸盐可使聚-L-赖氨酸以可溶于水的结晶形式存在。 在β结构中可能会发现少量的产物，因为HBr干扰氨基与羧基或含N或O部分之间的氢键。

存储类别

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000471636
0000471635
0000471636
0000471635
0000405469

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Volger OL, et al.
The American Journal of Pathology, 171, 326-337 (2007)
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The cellular prion protein (PrPC) fulfils several yet not completely understood physiological functions. Apart from these functions, it has the ability to misfold into a pathogenic scrapie form (PrPSc) leading to fatal transmissible spongiform encephalopathies. Proteolytic processing of PrPC generates
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Kuczkowski J et al.
American Journal of Otolaryngology, 31, 404-404 (2010)
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Product Information Sheet - P8920

全球贸易项目编号

货号GTIN
P8920-500ML04061838262134
P8920-100ML04061838262127

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