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Merck
CN

PLA0057

Rabbit anti-Mre11 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

别名:

AT-like disease, ATLD, DNA recombination and repair protein, HNGS1, MRE11, MRE11 double strand break repair nuclease A, MRE11 homolog, MRE11 homolog 1, MRE11 homolog A, MRE11 meiotic recombination 11 homolog A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae), MRE11 meiotic recombination 11-like protein A, MRE11B, double strand break repair nuclease A, endo/exonuclease Mre11, meiotic recombination (S. cerevisiae) 11 homolog A, meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
1

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

immunohistochemistry: 1:1,000-1:5,000, western blot: 1:1,000- 1:5,000

accession no.

NP_005582.1

UniProt accession no.

P49959

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rabbit ... Mre11(4361)

Immunogen

The epitope recognized by PLA0057 maps to a region between residues 1 and 50 of human Meiotic Recombination 11 homolog A using the numbering given in entry NP_005582.1 (GeneID 4361).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

Mre11 is a component of the MRN complex and plays a role in telomere maintenance and double-strand break (DSB) repair. Mre11 associates with rad50 in the MRN complex. Mre11 possesses 3′– 5′ exonuclease activity that is involved in creating DNA termini in DSB suitable for priming DNA synthesis and ligation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

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Beeke Wienert et al.
Science (New York, N.Y.), 364(6437), 286-289 (2019-04-20)
CRISPR-Cas genome editing induces targeted DNA damage but can also affect off-target sites. Current off-target discovery methods work using purified DNA or specific cellular models but are incapable of direct detection in vivo. We developed DISCOVER-Seq (discovery of in situ

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