PLA0085
Rabbit anti-Chk1 Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
别名:
1, CHK1, CHK1 (checkpoint; S.pombe) homolog, CHK1 checkpoint homolog, CHK1 checkpoint homolog (S. pombe), Checkpoint, Chk1-S, S. pombe, cell cycle checkpoint kinase, checkpoint kinase-1, homolog of
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, IP, WB
Citations:
1
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
technique(s)
immunohistochemistry: 1:1,000- 1:5,000, immunoprecipitation (IP): 2-10 μg/mg, western blot: 1:1,000-1:5,000
accession no.
O14757
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
rabbit ... Chk1(1111)
Immunogen
The epitope recognized by PLA0085 maps to a region between residues 250 and 300 of human Checkpoint Kinase 1 using the numbering given in SwissProt entry O14757 (GeneID 1111).
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Other Notes
Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Zheng-Wen Nie et al.
Cell cycle (Georgetown, Tex.), 16(22), 2220-2229 (2017-09-22)
Checkpoint 1 (Chk1), as an important member of DNA replication checkpoint and DNA damage response, has an important role during the G2/M stage of mitosis. In this study, we used porcine oocyte as a model to investigate the function of
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