PLA0126
Rabbit anti-Phospho 53BP1 (S25) Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
别名:
1, 53BP1, TDRD30, TP53, p202, p53-binding protein 1, p53BP1, tumor protein 53-binding protein, tumor protein p53-binding protein
产品名称
Rabbit anti-Phospho 53BP1 (S25) Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.
biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
species reactivity
mouse, human
technique(s)
immunohistochemistry: 1:1,000- 1:5,000
immunoprecipitation (IP): 1- 4 μg/mg
western blot: 1:2,000- 1:10,000
accession no.
NP_005648.1
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
phosphorylation (pSer25 )
Quality Level
Gene Information
human ... TP53BP1(7158)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Immunogen for PLA0126 was a phosphorylated synthetic peptide, which represented a portion of human p53 Binding Protein 1 (GeneID 7158) around serine 25 according to the numbering given in entry NP_005648.1.
Other Notes
53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.
Physical form
Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Devon Lundine et al.
Molecular cancer research : MCR, 20(12), 1799-1810 (2022-09-09)
The TP53 gene is mutated in 80% of triple-negative breast cancers. Cells that harbor the hot-spot p53 gene mutation R273H produce an oncogenic mutant p53 (mtp53) that enhances cell proliferative and metastatic properties. The enhanced activities of mtp53 are collectively
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