PLA0179
Rabbit anti-NBS1 Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
别名:
AT-V1, AT-V2, ATV, NBS, NBS1, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, P95, cell cycle regulatory protein p95, p95 protein of the MRE11/RAD50 complex
产品名称
Rabbit anti-NBS1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
technique(s)
immunohistochemistry: 1:100- 1:500
immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000
accession no.
NP_002476.2
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
rabbit ... NBS1(4683)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
The epitope recognized by PLA0179 maps to a region between residue 704 and 754 of human Nibrin using the numbering given in entry NP_002476.2 (GeneID 4683).
Other Notes
Mutations in NBS1 (Nijmegen Breakage Syndrome 1), also known as nibrin, are associated with the autosomal recessive syndrome, Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. At the cellular level, NBS1 is part of the MRE11/RAD50 double-strand break repair complex that is critical to the DNA damage response, DNA recombination, telomere integrity, and cell cycle checkpoint control.
Physical form
Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Jérémie Fages et al.
PLoS genetics, 16(6), e1008511-e1008511 (2020-07-01)
Ribosomal DNA (rDNA) is the most transcribed genomic region and contains hundreds of tandem repeats. Maintaining these rDNA repeats as well as the level of rDNA transcription is essential for cellular homeostasis. DNA damages generated in rDNA need to be
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